TY - JOUR
T1 - Neurological aspects of multiple myeloma and related disorders
AU - Dispenzieri, Angela
AU - Kyle, Robert A.
N1 - Funding Information:
This is supported in part by CA62242 from the National Cancer Institute and the Robert A. Kyle Hematologic Malignancies Fund.
PY - 2005/12
Y1 - 2005/12
N2 - The spectrum of neurologic complications of multiple myeloma (MM) and related conditions is as diverse as the conditions themselves. Complications range from direct compression (radiculopathy, spinal cord compression, base-of-the-skull tumor) to the infiltrative (amyloid, peripheral neuropathies, and numb chin syndrome of myeloma), the metabolic (slowed mentation from hyperviscosity, hypercalcemia, or uremia), and to autoimmune or cytokine-mediated (peripheral neuropathy). The two most common presentations are the compressive radiculopathy one sees in multiple myeloma and the peripheral neuropathies associated with many of the other disorders. The authors will review the neurologic complications of MM, monoclonal gammopathy of undetermined significance (MGUS), Waldenström macroglobulinemia (WM), POEMS syndrome, amyloidosis, and cryoglobulinemia.
AB - The spectrum of neurologic complications of multiple myeloma (MM) and related conditions is as diverse as the conditions themselves. Complications range from direct compression (radiculopathy, spinal cord compression, base-of-the-skull tumor) to the infiltrative (amyloid, peripheral neuropathies, and numb chin syndrome of myeloma), the metabolic (slowed mentation from hyperviscosity, hypercalcemia, or uremia), and to autoimmune or cytokine-mediated (peripheral neuropathy). The two most common presentations are the compressive radiculopathy one sees in multiple myeloma and the peripheral neuropathies associated with many of the other disorders. The authors will review the neurologic complications of MM, monoclonal gammopathy of undetermined significance (MGUS), Waldenström macroglobulinemia (WM), POEMS syndrome, amyloidosis, and cryoglobulinemia.
KW - Amyloidosis
KW - Cryoglobulinemia
KW - MGUS
KW - Multiple myeloma
KW - Neurologic complications
KW - POEMS syndrome
KW - Peripheral neuropathy
KW - Waldenström macroglobulinemia
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U2 - 10.1016/j.beha.2005.01.024
DO - 10.1016/j.beha.2005.01.024
M3 - Review article
C2 - 16026744
AN - SCOPUS:22144444911
SN - 1521-6926
VL - 18
SP - 673
EP - 688
JO - Best Practice and Research: Clinical Haematology
JF - Best Practice and Research: Clinical Haematology
IS - 4 SPEC. ISS.
ER -