Neurological abnormalities in caveolin-1 knock out mice

Eugenia Trushina, Jordan Du Charme, Joseph Parisi, Cynthia T. McMurray

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Caveolin-1 is the defining structural protein in caveolar vesicles, which regulate signal transduction and cholesterol trafficking in cells. In the brain, cav-1 is highly expressed in neurons and glia, but its function in those cell types is unclear. Mice deficient in cav-1 (CavKO) have been developed to test functional roles for cav-1 in various tissues. However, neurological phenotypes associated with loss of cav-1 in mice have not been evaluated. Here, we report the results of motor and behavioral testing of CavKO mice. We find that mice deficient in cav-1 have reduced brain weight and display a number of motor and behavioral abnormalities. CavKO mice develop neurological phenotypes including clasping, abnormal spinning, muscle weakness, reduced activity, and gait abnormalities. These data suggest that cav-1 is involved in maintaining cortico-striato-pallido-thalamo-pontine pathways associated with motor control.

Original languageEnglish (US)
Pages (from-to)24-32
Number of pages9
JournalBehavioural Brain Research
Volume172
Issue number1
DOIs
StatePublished - Sep 15 2006

Keywords

  • Brain histology
  • Caveolin
  • Knock out mouse model
  • Neurological phenotype

ASJC Scopus subject areas

  • Behavioral Neuroscience

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