Neurologic Complications: Effects of Ipilimumab and Nivolumab Therapy in Patients With Metastatic Melanoma

Jessica Latchman, Ann Guastella, Cindy Tofthagen

Research output: Contribution to journalArticle


Checkpoint inhibitors are a form of immunotherapy that have revolutionized treatment for malignant melanoma, resulting in longer survival and better disease control. Multiple autoimmune disorders can occur with the use of checkpoint inhibitors, including severe, potentially fatal neurologic complications. Although neurologic complications are uncommon, their early recognition and treatment is required. The purpose of this article is to present information on neurologic complications of ipilimumab and nivolumab to inform nursing practice. Recommendations for evaluation and treatment of neurologic complications are reviewed.

Original languageEnglish (US)
Pages (from-to)355-358
Number of pages4
JournalClinical journal of oncology nursing
Issue number4
StatePublished - Aug 1 2019



  • immunotherapy
  • management
  • melanoma
  • neurologic complications
  • side effects

ASJC Scopus subject areas

  • Oncology
  • Oncology(nursing)

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