Neurologic aspects of monoclonal gammopathy of undetermined significance, multiple myeloma, and related disorders

Robert A. Kyle, Angela Dispenzieri

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Radiculopathy is the single most frequent neurologic complication of multiple myeloma. It usually involves the thoracic or lumbosacral area, and results from compression of the nerve root by a paravertebral plasmacytoma or by the collapsed bone itself. Compression of the spinal cord from an extramedullary plasmacytoma occurs in 5% of patients with myeloma during the course of their disease. Rarely, myeloma cells diffusely infiltrate the meninges. Intracranial plasmacytomas most commonly arise in the base of the skull and represent myelomatous lesions from bone. Softtissue plasmacytomas of the central nervous system are rare. Peripheral sensorimotor peripheral neuropathy is uncommon in multiple myeloma; when present, it is usually caused by amyloidosis or osteosclerotic myeloma.

Original languageEnglish (US)
Title of host publicationMultiple Myeloma and Related Disorders
PublisherCRC Press
Pages350-365
Number of pages16
ISBN (Electronic)9781444114140
ISBN (Print)9780340810101
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Medicine(all)

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