Neuroimmune interaction in seizures and epilepsy: focusing on monocyte infiltration

Dale B. Bosco, Dai Shi Tian, Long Jun Wu

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Epilepsy is a major neurological condition that affects millions of people globally. While a number of interventions have been developed to mitigate this condition, a significant number of patients are refractory to these treatments. Consequently, other avenues of research are needed. One such avenue is modulation of the immune system response to this condition, which has mostly focused on microglia, the resident immune cells of the central nervous system (CNS). However, other immune cells can impact neurological conditions, principally blood-borne monocytes that can infiltrate into brain parenchyma after seizures. As such, this review will first discuss how monocytes can be recruited to the CNS and how they can be distinguished from there immunological cousins, microglia. Then, we will explore what is known about the role monocytes have within seizure pathogenesis and epilepsy. Considering how little is known about monocyte function in seizure- and epilepsy-related pathologies, further studies are warranted that investigate infiltrated blood-borne monocytes as a potential therapeutic target for epilepsy treatment.

Original languageEnglish (US)
Pages (from-to)4822-4837
Number of pages16
JournalFEBS Journal
Volume287
Issue number22
DOIs
StatePublished - Nov 2020

Keywords

  • blood–brainbarrier
  • epilepsy
  • inflammation
  • microglia
  • monocyte recruitment
  • monocytes
  • seizures

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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