TY - JOUR
T1 - Neuroimmune disorders of the central nervous system in children in the molecular era
AU - Wells, Elizabeth
AU - Hacohen, Yael
AU - Waldman, Amy
AU - Tillema, Jan M.
AU - Soldatos, Ariane
AU - Ances, Beau
AU - Benseler, Susanne
AU - Bielekova, Bibi
AU - Dale, Russel C.
AU - Dalmau, Josep
AU - Gaillard, William
AU - Gorman, Mark
AU - Greenberg, Benjamin
AU - Hyslop, Ann
AU - Pardo, Carlos A.
AU - Tasker, Robert C.
AU - Yeh, E. Ann
AU - Bar-Or, Amit
AU - Pittock, Sean
AU - Vanderver, Adeline
AU - Banwell, Brenda
N1 - Publisher Copyright:
© 2018 Macmillan Publishers Ltd., part of Springer Nature.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Immune-mediated disorders of the CNS in children are a complex group of demyelinating, inflammatory, parainfectious and postinfectious disorders with heterogeneous pathobiological mechanisms and clinical manifestations, often associated with fundamental derangement in immune regulation. In this Review, we aim to provide an update on our knowledge of neuroimmune disorders and highlight areas of research that are priorities for improving clinical management. We outline the clinical features of neuroimmune disorders, the current approaches to their treatment and new approaches in development. We then consider the pathological features, including biomarkers, pathological mechanisms and genetics, and discuss the value of immune assays in clinical investigation and basic research. On the basis of current knowledge and techniques, we propose four research priorities: Rigorous and consistent collection of core clinical data, cooperative investigation of treatments, development of biological assays and genetic studies. These priorities should help us to achieve the shared goal of precision medicine for neuroimmune disorders. However, multicentre research and the creation of clinical consortia for these rare disorders will be necessary, and we hope that this Review serves as a call to action that is timely given current exciting advances in neuroimmune therapeutics.
AB - Immune-mediated disorders of the CNS in children are a complex group of demyelinating, inflammatory, parainfectious and postinfectious disorders with heterogeneous pathobiological mechanisms and clinical manifestations, often associated with fundamental derangement in immune regulation. In this Review, we aim to provide an update on our knowledge of neuroimmune disorders and highlight areas of research that are priorities for improving clinical management. We outline the clinical features of neuroimmune disorders, the current approaches to their treatment and new approaches in development. We then consider the pathological features, including biomarkers, pathological mechanisms and genetics, and discuss the value of immune assays in clinical investigation and basic research. On the basis of current knowledge and techniques, we propose four research priorities: Rigorous and consistent collection of core clinical data, cooperative investigation of treatments, development of biological assays and genetic studies. These priorities should help us to achieve the shared goal of precision medicine for neuroimmune disorders. However, multicentre research and the creation of clinical consortia for these rare disorders will be necessary, and we hope that this Review serves as a call to action that is timely given current exciting advances in neuroimmune therapeutics.
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U2 - 10.1038/s41582-018-0024-9
DO - 10.1038/s41582-018-0024-9
M3 - Review article
C2 - 29925924
AN - SCOPUS:85048707895
SN - 1759-4758
VL - 14
SP - 433
EP - 445
JO - Nature Reviews Neurology
JF - Nature Reviews Neurology
IS - 7
ER -