Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

Jean Christophe Delpech, Shawn Herron, Mina B. Botros, Tsuneya Ikezu

Research output: Contribution to journalReview articlepeer-review

Abstract

The dynamics of CNS function rely upon omnidirectional communication among CNS cell types. Extracellular vesicles (EVs) have emerged as key mediators of this communication and are actively involved in response to CNS injury, mediating inflammatory response and inflammation-related neuroprotection as they display dual beneficial and detrimental roles. Neuroimmune interactions include communication between neurons and microglia, the resident macrophages within the CNS, and these interactions are a critical mediator of healthy brain functions, mounting an inflammatory response, and disease pathogenesis. This review aims to organize recent research highlighting the role of EVs in health and neurodegenerative disorders, with a specific focus on neuroimmune interactions between neurons and glia in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)361-372
Number of pages12
JournalTrends in neurosciences
Volume42
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • Alzheimer's disease
  • astrocyte
  • exosome
  • extracellular vesicle
  • microglia
  • myelin
  • neurodegeneration
  • neuron
  • oligodendrocyte

ASJC Scopus subject areas

  • Neuroscience(all)

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