Neuroimaging across the FTD spectrum

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Frontotemporal dementia is a complex and heterogeneous neurodegenerative disease that encompasses many clinical syndromes, pathological diseases, and genetic mutations. Neuroimaging has played a critical role in our understanding of the underlying pathophysiology of frontotemporal dementia and provided biomarkers to aid diagnosis. Early studies defined patterns of neurodegeneration and hypometabolism associated with the clinical, pathological and genetic aspects of frontotemporal dementia, with more recent studies highlighting how the breakdown of structural and functional brain networks define frontotemporal dementia. Molecular positron emission tomography ligands allowing the in vivo imaging of tau proteins have also provided important insights, although more work is needed to understand the biology of the currently available ligands.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
DOIs
StatePublished - Jan 1 2019

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Fingerprint

Frontotemporal Dementia
Neuroimaging
Ligands
tau Proteins
Inborn Genetic Diseases
Neurodegenerative Diseases
Positron-Emission Tomography
Biomarkers
Mutation
Brain

Keywords

  • Agrammatic
  • Apraxia of speech
  • Connectivity
  • MRI
  • Neurodegeneration
  • Progranulin, C9ORF72
  • Semantic
  • Tau
  • TDP-43

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Whitwell, J. L. (2019). Neuroimaging across the FTD spectrum. In Progress in Molecular Biology and Translational Science (Progress in Molecular Biology and Translational Science). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2019.05.009

Neuroimaging across the FTD spectrum. / Whitwell, Jennifer Lynn.

Progress in Molecular Biology and Translational Science. Elsevier B.V., 2019. (Progress in Molecular Biology and Translational Science).

Research output: Chapter in Book/Report/Conference proceedingChapter

Whitwell, JL 2019, Neuroimaging across the FTD spectrum. in Progress in Molecular Biology and Translational Science. Progress in Molecular Biology and Translational Science, Elsevier B.V. https://doi.org/10.1016/bs.pmbts.2019.05.009
Whitwell JL. Neuroimaging across the FTD spectrum. In Progress in Molecular Biology and Translational Science. Elsevier B.V. 2019. (Progress in Molecular Biology and Translational Science). https://doi.org/10.1016/bs.pmbts.2019.05.009
Whitwell, Jennifer Lynn. / Neuroimaging across the FTD spectrum. Progress in Molecular Biology and Translational Science. Elsevier B.V., 2019. (Progress in Molecular Biology and Translational Science).
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