Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy

Peter J Dyck, J. C. Stevens, P. C. O'Brien, K. F. Oviatt, A. C. Lais, M. B. Coventry, J. W. Beabout

Research output: Contribution to journalArticle

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Abstract

Some patients with radiologic findings of neurogenic arthropathy or multiple fractures do not exhibit overt neurologic signs. Results of nerve conduction velocity, computer-assisted sensory examination, periosteal nociception, and morphometric and graded teased-fiber evaluation of cutaneous nerves allowed us to recognize a mild neuropathic abnormality. Neurogenic arthropathy and subclinical neuropathy were also found in relatives. In three kinships, the underlying disorder was probably hereditary sensory neuropathy type 1 and in several others, it was recessively inherited sensory neuropathy. These arthropathies were often painful, and overt loss of superficial and deep pain sensation was not a prominent or necessary condition. An interplay of multiple factors including insensitivity, trauma, obesity, activity, abuse, peronality, mental subnormality, and metabolic joint and bone disease are probaly involved in the development of the bony lesions and thus provide further evidence that environmental factors affect expression of human mutant genes for inherited neuropathy.

Original languageEnglish (US)
Pages (from-to)357-367
Number of pages11
JournalNeurology
Volume33
Issue number3
StatePublished - 1983

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Neurogenic Arthropathy
Joint Diseases
Hereditary Sensory and Autonomic Neuropathies
Nociception
Metabolic Bone Diseases
Neural Conduction
Neurologic Manifestations
Obesity
Pain
Skin
Wounds and Injuries
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dyck, P. J., Stevens, J. C., O'Brien, P. C., Oviatt, K. F., Lais, A. C., Coventry, M. B., & Beabout, J. W. (1983). Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. Neurology, 33(3), 357-367.

Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. / Dyck, Peter J; Stevens, J. C.; O'Brien, P. C.; Oviatt, K. F.; Lais, A. C.; Coventry, M. B.; Beabout, J. W.

In: Neurology, Vol. 33, No. 3, 1983, p. 357-367.

Research output: Contribution to journalArticle

Dyck, PJ, Stevens, JC, O'Brien, PC, Oviatt, KF, Lais, AC, Coventry, MB & Beabout, JW 1983, 'Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy', Neurology, vol. 33, no. 3, pp. 357-367.
Dyck PJ, Stevens JC, O'Brien PC, Oviatt KF, Lais AC, Coventry MB et al. Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. Neurology. 1983;33(3):357-367.
Dyck, Peter J ; Stevens, J. C. ; O'Brien, P. C. ; Oviatt, K. F. ; Lais, A. C. ; Coventry, M. B. ; Beabout, J. W. / Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. In: Neurology. 1983 ; Vol. 33, No. 3. pp. 357-367.
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