Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19

Young Erben; Mercedes Prudencio; Christopher P. Marquez; Karen R. Jansen-West; Michael G. Heckman; Launia J. White; Judith A. Dunmore; Casey N. Cook; Meredith T. Lilley; Neda Qosja; Yuping Song; Rana Hanna Al Shaikh; Lillian M. Daughrity; Jordan L. Bartfield; Gregory S. Day; Björn Oskarsson; Katharine A. Nicholson; Zbigniew K. Wszolek; Jonathan B. Hoyne; Tania F. Gendron; James F. Meschia; Leonard Petrucelli

doi:10.1016/j.isci.2022.105272

Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19

Young Erben, Mercedes Prudencio, Christopher P. Marquez, Karen R. Jansen-West, Michael G. Heckman, Launia J. White, Judith A. Dunmore, Casey N. Cook, Meredith T. Lilley, Neda Qosja, Yuping Song, Rana Hanna Al Shaikh, Lillian M. Daughrity, Jordan L. Bartfield, Gregory S. Day, Björn Oskarsson, Katharine A. Nicholson, Zbigniew K. Wszolek, Jonathan B. Hoyne, Tania F. GendronJames F. Meschia, Leonard Petrucelli

Research output: Contribution to journal › Article › peer-review

Abstract

Blood neurofilament light chain (NFL) is proposed to serve as an estimate of disease severity in hospitalized patients with coronavirus disease 2019 (COVID-19). We show that NFL concentrations in plasma collected from 880 patients with COVID-19 within 5 days of hospital admission were elevated compared to controls. Higher plasma NFL associated with worse clinical outcomes including the need for mechanical ventilation, intensive care, prolonged hospitalization, and greater functional disability at discharge. No difference in the studied clinical outcomes between black/African American and white patients was found. Finally, vaccination associated with less disability at time of hospital discharge. In aggregate, our findings support the utility of measuring NFL shortly after hospital admission to estimate disease severity and show that race does not influence clinical outcomes caused by COVID-19 assuming equivalent access to care, and that vaccination may lessen the degree of COVID-19-caused disability.

Original language	English (US)
Article number	105272
Journal	iScience
Volume	25
Issue number	11
DOIs	https://doi.org/10.1016/j.isci.2022.105272
State	Published - Nov 18 2022

Keywords

Biological sciences
Immunology
Virology

ASJC Scopus subject areas

General

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10.1016/j.isci.2022.105272

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Erben, Y., Prudencio, M., Marquez, C. P., Jansen-West, K. R., Heckman, M. G., White, L. J., Dunmore, J. A., Cook, C. N., Lilley, M. T., Qosja, N., Song, Y., Hanna Al Shaikh, R., Daughrity, L. M., Bartfield, J. L., Day, G. S., Oskarsson, B., Nicholson, K. A., Wszolek, Z. K., Hoyne, J. B., ... Petrucelli, L. (2022). Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19. iScience, 25(11), Article 105272. https://doi.org/10.1016/j.isci.2022.105272

Erben, Y, Prudencio, M, Marquez, CP, Jansen-West, KR, Heckman, MG, White, LJ, Dunmore, JA, Cook, CN, Lilley, MT, Qosja, N, Song, Y, Hanna Al Shaikh, R, Daughrity, LM, Bartfield, JL, Day, GS, Oskarsson, B, Nicholson, KA, Wszolek, ZK, Hoyne, JB, Gendron, TF , Meschia, JF & Petrucelli, L 2022, 'Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19', iScience, vol. 25, no. 11, 105272. https://doi.org/10.1016/j.isci.2022.105272

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title = "Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19",

abstract = "Blood neurofilament light chain (NFL) is proposed to serve as an estimate of disease severity in hospitalized patients with coronavirus disease 2019 (COVID-19). We show that NFL concentrations in plasma collected from 880 patients with COVID-19 within 5 days of hospital admission were elevated compared to controls. Higher plasma NFL associated with worse clinical outcomes including the need for mechanical ventilation, intensive care, prolonged hospitalization, and greater functional disability at discharge. No difference in the studied clinical outcomes between black/African American and white patients was found. Finally, vaccination associated with less disability at time of hospital discharge. In aggregate, our findings support the utility of measuring NFL shortly after hospital admission to estimate disease severity and show that race does not influence clinical outcomes caused by COVID-19 assuming equivalent access to care, and that vaccination may lessen the degree of COVID-19-caused disability.",

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author = "Young Erben and Mercedes Prudencio and Marquez, {Christopher P.} and Jansen-West, {Karen R.} and Heckman, {Michael G.} and White, {Launia J.} and Dunmore, {Judith A.} and Cook, {Casey N.} and Lilley, {Meredith T.} and Neda Qosja and Yuping Song and {Hanna Al Shaikh}, Rana and Daughrity, {Lillian M.} and Bartfield, {Jordan L.} and Day, {Gregory S.} and Bj{\"o}rn Oskarsson and Nicholson, {Katharine A.} and Wszolek, {Zbigniew K.} and Hoyne, {Jonathan B.} and Gendron, {Tania F.} and Meschia, {James F.} and Leonard Petrucelli",

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doi = "10.1016/j.isci.2022.105272",

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T1 - Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19

AU - Erben, Young

AU - Prudencio, Mercedes

AU - Marquez, Christopher P.

AU - Jansen-West, Karen R.

AU - Heckman, Michael G.

AU - White, Launia J.

AU - Dunmore, Judith A.

AU - Cook, Casey N.

AU - Lilley, Meredith T.

AU - Qosja, Neda

AU - Song, Yuping

AU - Hanna Al Shaikh, Rana

AU - Daughrity, Lillian M.

AU - Bartfield, Jordan L.

AU - Day, Gregory S.

AU - Oskarsson, Björn

AU - Nicholson, Katharine A.

AU - Wszolek, Zbigniew K.

AU - Hoyne, Jonathan B.

AU - Gendron, Tania F.

AU - Meschia, James F.

AU - Petrucelli, Leonard

PY - 2022/11/18

Y1 - 2022/11/18

N2 - Blood neurofilament light chain (NFL) is proposed to serve as an estimate of disease severity in hospitalized patients with coronavirus disease 2019 (COVID-19). We show that NFL concentrations in plasma collected from 880 patients with COVID-19 within 5 days of hospital admission were elevated compared to controls. Higher plasma NFL associated with worse clinical outcomes including the need for mechanical ventilation, intensive care, prolonged hospitalization, and greater functional disability at discharge. No difference in the studied clinical outcomes between black/African American and white patients was found. Finally, vaccination associated with less disability at time of hospital discharge. In aggregate, our findings support the utility of measuring NFL shortly after hospital admission to estimate disease severity and show that race does not influence clinical outcomes caused by COVID-19 assuming equivalent access to care, and that vaccination may lessen the degree of COVID-19-caused disability.

AB - Blood neurofilament light chain (NFL) is proposed to serve as an estimate of disease severity in hospitalized patients with coronavirus disease 2019 (COVID-19). We show that NFL concentrations in plasma collected from 880 patients with COVID-19 within 5 days of hospital admission were elevated compared to controls. Higher plasma NFL associated with worse clinical outcomes including the need for mechanical ventilation, intensive care, prolonged hospitalization, and greater functional disability at discharge. No difference in the studied clinical outcomes between black/African American and white patients was found. Finally, vaccination associated with less disability at time of hospital discharge. In aggregate, our findings support the utility of measuring NFL shortly after hospital admission to estimate disease severity and show that race does not influence clinical outcomes caused by COVID-19 assuming equivalent access to care, and that vaccination may lessen the degree of COVID-19-caused disability.

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Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19

Abstract

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