Neurofibrillary degeneration and microtubule associated protein tau.

S. H. Yen, W. K. Liu

Research output: Contribution to journalArticle

Abstract

Alzheimer disease is characterized by neurofibrillary pathology containing paired helical filaments (PHF). These abnormal filaments consist of a modified form of microtubule associated protein tau. The modification involves phosphorylation. In this mini review, we summarize recent studies regarding the differences between normal tau and PHF-tau, focusing especially on the extent and the site of phosphorylation. We also discuss the mechanisms possible involved in the development of PHF.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalChinese Journal of Physiology
Volume35
Issue number4
StatePublished - 1992
Externally publishedYes

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Microtubule-Associated Proteins
Phosphorylation
Alzheimer Disease
Pathology

ASJC Scopus subject areas

  • Physiology

Cite this

Neurofibrillary degeneration and microtubule associated protein tau. / Yen, S. H.; Liu, W. K.

In: Chinese Journal of Physiology, Vol. 35, No. 4, 1992, p. 357-366.

Research output: Contribution to journalArticle

Yen, S. H. ; Liu, W. K. / Neurofibrillary degeneration and microtubule associated protein tau. In: Chinese Journal of Physiology. 1992 ; Vol. 35, No. 4. pp. 357-366.
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