Neurofibrillary degeneration and microtubule associated protein tau.

S. H. Yen, W. K. Liu

Research output: Contribution to journalArticle


Alzheimer disease is characterized by neurofibrillary pathology containing paired helical filaments (PHF). These abnormal filaments consist of a modified form of microtubule associated protein tau. The modification involves phosphorylation. In this mini review, we summarize recent studies regarding the differences between normal tau and PHF-tau, focusing especially on the extent and the site of phosphorylation. We also discuss the mechanisms possible involved in the development of PHF.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalChinese Journal of Physiology
Issue number4
StatePublished - 1992
Externally publishedYes


ASJC Scopus subject areas

  • Physiology

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