Neuroendocrine alterations in the somatotrophic axis in chronic renal failure

J. D. Veldhuis, M. L. Johnson, M. J. Wilkowski, A. Iranmanesh, W. K. Bolton

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Both secretion and metabolic clearance of GH in health and disease are subject to regulation by an array of metabolic, nutritional, physical activity, age, and body composition cues. Moreover, both GH and its mediators (e.g. IGF-I) are bound in plasma by one or more high-affinity binding proteins. Accordingly, carefully designed clinical and basic investigations are required to examine and clarify the diverse alterations in the dynamics of the somatotrophic axis that accompany the syndrome of CRF with its attendant attenuation of normal anabolism, growth and development.

Original languageEnglish (US)
Pages (from-to)12-22
Number of pages11
JournalActa Paediatrica Scandinavica, Supplement
Volume80
Issue number379
StatePublished - 1991

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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