TY - JOUR
T1 - Neurodegeneration with dementia
T2 - From fundamentals of pathology to clinical imaging by MRI and SPECT
AU - Cordes, Michael
AU - Wszolek, Zbigniew
AU - Brück, Wolfgang
AU - Zimny, Anna
AU - Sasiadek, Marek
AU - Kuwert, Torsten
N1 - Publisher Copyright:
©2016 Bentham Science Publishers.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - The increasing incidence of neurodegenerative disorders with dementia (NDD) requires structural and functional imaging methods which are easily available in the clinical setting. The diagnostic work-up for patients who have NDD includes magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and positron emission tomography (PET). Both, MRI and SPECT can show characteristic findings of NDD. However, the interpretation of these findings has to be done in the context of clinical data, which includes biochemical and histological examinations. In this article, we review recent advances in pathology and the impact of these advances on MRI and SPECT studies interpretations. We present a literature review describing typical MRI and SPECT findings and the diagnostic accuracies reported for NDD. Combining MRI and SPECT examinations with quantitative evaluation of clinical data further improves the diagnostic potential of these imaging procedures for NDD.
AB - The increasing incidence of neurodegenerative disorders with dementia (NDD) requires structural and functional imaging methods which are easily available in the clinical setting. The diagnostic work-up for patients who have NDD includes magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and positron emission tomography (PET). Both, MRI and SPECT can show characteristic findings of NDD. However, the interpretation of these findings has to be done in the context of clinical data, which includes biochemical and histological examinations. In this article, we review recent advances in pathology and the impact of these advances on MRI and SPECT studies interpretations. We present a literature review describing typical MRI and SPECT findings and the diagnostic accuracies reported for NDD. Combining MRI and SPECT examinations with quantitative evaluation of clinical data further improves the diagnostic potential of these imaging procedures for NDD.
KW - Alzheimer´s disease
KW - Frontotemporal lobe dementia
KW - Lewy body dementia
KW - MRI
KW - Neurodegenerative disorders with dementia
KW - SPECT
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U2 - 10.2174/1573405612666160606105654
DO - 10.2174/1573405612666160606105654
M3 - Review article
AN - SCOPUS:84995610502
SN - 1573-4056
VL - 12
SP - 257
EP - 268
JO - Current Medical Imaging Reviews
JF - Current Medical Imaging Reviews
IS - 4
ER -