TY - JOUR
T1 - Neurocognitive outcomes in congenital diaphragmatic hernia survivors
T2 - a cross-sectional prospective study
AU - Bojanić, Katarina
AU - Grubić, Marina
AU - Bogdanić, Ana
AU - Vuković, Jurica
AU - Weingarten, Toby N.
AU - Huebner, Andrea R.
AU - Sprung, Juraj
AU - Schroeder, Darrell R.
AU - Grizelj, Ruža
N1 - Publisher Copyright:
© 2016
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background/purpose Congenital diaphragmatic hernia (CDH) survivors may have persistent neurocognitive delays. We assessed neurodevelopmental outcomes in CDH survivors from infancy to late teenage years. Methods A cross-sectional study was conducted on 37 CDH survivors to examine neurocognitive functioning. Overall cognitive score was tested with the early learning composite (ELC) of Mullen Scales of Early Learning (n = 19), and Full Scale IQ (FSIQ) of Wechsler Intelligence Scale for Children–Fourth Edition (n = 18). Results ELC was 85.7 ± 16.4, lower than the expected norm of 100, P = 0.004, and 6 survivors had moderate, and 3 severe delay, which is not greater than expected in the general population (P = 0.148). FSIQ was 99.6 ± 19.1, consistent with the expected norm of 100, P = 0.922, and 3 survivors had moderate and 2 severe delay, which is greater than expected (P = 0.048). Although ELC was lower than FSIQ (P = 0.024), within each testing group overall cognitive ability was not associated with participant age (ELC, P = 0.732; FSIQ, P = 0.909). Longer hospital stay was the only factor found to be consistently associated with a worse cognitive score across all participants in our cohort. Conclusions A high percentage of survivors with CDH have moderate to severe cognitive impairment suggesting that these subjects warrant early testing with implementation of therapeutic and educational interventions.
AB - Background/purpose Congenital diaphragmatic hernia (CDH) survivors may have persistent neurocognitive delays. We assessed neurodevelopmental outcomes in CDH survivors from infancy to late teenage years. Methods A cross-sectional study was conducted on 37 CDH survivors to examine neurocognitive functioning. Overall cognitive score was tested with the early learning composite (ELC) of Mullen Scales of Early Learning (n = 19), and Full Scale IQ (FSIQ) of Wechsler Intelligence Scale for Children–Fourth Edition (n = 18). Results ELC was 85.7 ± 16.4, lower than the expected norm of 100, P = 0.004, and 6 survivors had moderate, and 3 severe delay, which is not greater than expected in the general population (P = 0.148). FSIQ was 99.6 ± 19.1, consistent with the expected norm of 100, P = 0.922, and 3 survivors had moderate and 2 severe delay, which is greater than expected (P = 0.048). Although ELC was lower than FSIQ (P = 0.024), within each testing group overall cognitive ability was not associated with participant age (ELC, P = 0.732; FSIQ, P = 0.909). Longer hospital stay was the only factor found to be consistently associated with a worse cognitive score across all participants in our cohort. Conclusions A high percentage of survivors with CDH have moderate to severe cognitive impairment suggesting that these subjects warrant early testing with implementation of therapeutic and educational interventions.
KW - Congenital diaphragmatic hernia
KW - Cross-sectional study
KW - Early learning composite score, ELC
KW - Full scale IQ, FSIQ
KW - Mullen Scales of Early Learning, MSEL
KW - Wechsler Intelligence Scale–Fourth Edition, WISC-IV
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U2 - 10.1016/j.jpedsurg.2016.05.011
DO - 10.1016/j.jpedsurg.2016.05.011
M3 - Article
C2 - 27519557
AN - SCOPUS:84990943356
SN - 0022-3468
VL - 51
SP - 1627
EP - 1634
JO - Journal of pediatric surgery
JF - Journal of pediatric surgery
IS - 10
ER -