Neurocognitive outcomes in congenital diaphragmatic hernia survivors: a cross-sectional prospective study

Katarina Bojanić, Marina Grubić, Ana Bogdanić, Jurica Vuković, Toby N. Weingarten, Andrea Huebner, Juraj Sprung, Darrell R. Schroeder, Ruža Grizelj

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/purpose Congenital diaphragmatic hernia (CDH) survivors may have persistent neurocognitive delays. We assessed neurodevelopmental outcomes in CDH survivors from infancy to late teenage years. Methods A cross-sectional study was conducted on 37 CDH survivors to examine neurocognitive functioning. Overall cognitive score was tested with the early learning composite (ELC) of Mullen Scales of Early Learning (n = 19), and Full Scale IQ (FSIQ) of Wechsler Intelligence Scale for Children–Fourth Edition (n = 18). Results ELC was 85.7 ± 16.4, lower than the expected norm of 100, P = 0.004, and 6 survivors had moderate, and 3 severe delay, which is not greater than expected in the general population (P = 0.148). FSIQ was 99.6 ± 19.1, consistent with the expected norm of 100, P = 0.922, and 3 survivors had moderate and 2 severe delay, which is greater than expected (P = 0.048). Although ELC was lower than FSIQ (P = 0.024), within each testing group overall cognitive ability was not associated with participant age (ELC, P = 0.732; FSIQ, P = 0.909). Longer hospital stay was the only factor found to be consistently associated with a worse cognitive score across all participants in our cohort. Conclusions A high percentage of survivors with CDH have moderate to severe cognitive impairment suggesting that these subjects warrant early testing with implementation of therapeutic and educational interventions.

Original languageEnglish (US)
Pages (from-to)1627-1634
Number of pages8
JournalJournal of Pediatric Surgery
Volume51
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

Cross-Sectional Studies
Learning
Prospective Studies
Wechsler Scales
Aptitude
Intelligence
Length of Stay
Congenital Diaphragmatic Hernias
Population
Therapeutics

Keywords

  • Congenital diaphragmatic hernia
  • Cross-sectional study
  • Early learning composite score, ELC
  • Full scale IQ, FSIQ
  • Mullen Scales of Early Learning, MSEL
  • Wechsler Intelligence Scale–Fourth Edition, WISC-IV

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Neurocognitive outcomes in congenital diaphragmatic hernia survivors : a cross-sectional prospective study. / Bojanić, Katarina; Grubić, Marina; Bogdanić, Ana; Vuković, Jurica; Weingarten, Toby N.; Huebner, Andrea; Sprung, Juraj; Schroeder, Darrell R.; Grizelj, Ruža.

In: Journal of Pediatric Surgery, Vol. 51, No. 10, 01.10.2016, p. 1627-1634.

Research output: Contribution to journalArticle

Bojanić, K, Grubić, M, Bogdanić, A, Vuković, J, Weingarten, TN, Huebner, A, Sprung, J, Schroeder, DR & Grizelj, R 2016, 'Neurocognitive outcomes in congenital diaphragmatic hernia survivors: a cross-sectional prospective study', Journal of Pediatric Surgery, vol. 51, no. 10, pp. 1627-1634. https://doi.org/10.1016/j.jpedsurg.2016.05.011
Bojanić, Katarina ; Grubić, Marina ; Bogdanić, Ana ; Vuković, Jurica ; Weingarten, Toby N. ; Huebner, Andrea ; Sprung, Juraj ; Schroeder, Darrell R. ; Grizelj, Ruža. / Neurocognitive outcomes in congenital diaphragmatic hernia survivors : a cross-sectional prospective study. In: Journal of Pediatric Surgery. 2016 ; Vol. 51, No. 10. pp. 1627-1634.
@article{3fbf25b3c55b4fd39d1121dff5089291,
title = "Neurocognitive outcomes in congenital diaphragmatic hernia survivors: a cross-sectional prospective study",
abstract = "Background/purpose Congenital diaphragmatic hernia (CDH) survivors may have persistent neurocognitive delays. We assessed neurodevelopmental outcomes in CDH survivors from infancy to late teenage years. Methods A cross-sectional study was conducted on 37 CDH survivors to examine neurocognitive functioning. Overall cognitive score was tested with the early learning composite (ELC) of Mullen Scales of Early Learning (n = 19), and Full Scale IQ (FSIQ) of Wechsler Intelligence Scale for Children–Fourth Edition (n = 18). Results ELC was 85.7 ± 16.4, lower than the expected norm of 100, P = 0.004, and 6 survivors had moderate, and 3 severe delay, which is not greater than expected in the general population (P = 0.148). FSIQ was 99.6 ± 19.1, consistent with the expected norm of 100, P = 0.922, and 3 survivors had moderate and 2 severe delay, which is greater than expected (P = 0.048). Although ELC was lower than FSIQ (P = 0.024), within each testing group overall cognitive ability was not associated with participant age (ELC, P = 0.732; FSIQ, P = 0.909). Longer hospital stay was the only factor found to be consistently associated with a worse cognitive score across all participants in our cohort. Conclusions A high percentage of survivors with CDH have moderate to severe cognitive impairment suggesting that these subjects warrant early testing with implementation of therapeutic and educational interventions.",
keywords = "Congenital diaphragmatic hernia, Cross-sectional study, Early learning composite score, ELC, Full scale IQ, FSIQ, Mullen Scales of Early Learning, MSEL, Wechsler Intelligence Scale–Fourth Edition, WISC-IV",
author = "Katarina Bojanić and Marina Grubić and Ana Bogdanić and Jurica Vuković and Weingarten, {Toby N.} and Andrea Huebner and Juraj Sprung and Schroeder, {Darrell R.} and Ruža Grizelj",
year = "2016",
month = "10",
day = "1",
doi = "10.1016/j.jpedsurg.2016.05.011",
language = "English (US)",
volume = "51",
pages = "1627--1634",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "10",

}

TY - JOUR

T1 - Neurocognitive outcomes in congenital diaphragmatic hernia survivors

T2 - a cross-sectional prospective study

AU - Bojanić, Katarina

AU - Grubić, Marina

AU - Bogdanić, Ana

AU - Vuković, Jurica

AU - Weingarten, Toby N.

AU - Huebner, Andrea

AU - Sprung, Juraj

AU - Schroeder, Darrell R.

AU - Grizelj, Ruža

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background/purpose Congenital diaphragmatic hernia (CDH) survivors may have persistent neurocognitive delays. We assessed neurodevelopmental outcomes in CDH survivors from infancy to late teenage years. Methods A cross-sectional study was conducted on 37 CDH survivors to examine neurocognitive functioning. Overall cognitive score was tested with the early learning composite (ELC) of Mullen Scales of Early Learning (n = 19), and Full Scale IQ (FSIQ) of Wechsler Intelligence Scale for Children–Fourth Edition (n = 18). Results ELC was 85.7 ± 16.4, lower than the expected norm of 100, P = 0.004, and 6 survivors had moderate, and 3 severe delay, which is not greater than expected in the general population (P = 0.148). FSIQ was 99.6 ± 19.1, consistent with the expected norm of 100, P = 0.922, and 3 survivors had moderate and 2 severe delay, which is greater than expected (P = 0.048). Although ELC was lower than FSIQ (P = 0.024), within each testing group overall cognitive ability was not associated with participant age (ELC, P = 0.732; FSIQ, P = 0.909). Longer hospital stay was the only factor found to be consistently associated with a worse cognitive score across all participants in our cohort. Conclusions A high percentage of survivors with CDH have moderate to severe cognitive impairment suggesting that these subjects warrant early testing with implementation of therapeutic and educational interventions.

AB - Background/purpose Congenital diaphragmatic hernia (CDH) survivors may have persistent neurocognitive delays. We assessed neurodevelopmental outcomes in CDH survivors from infancy to late teenage years. Methods A cross-sectional study was conducted on 37 CDH survivors to examine neurocognitive functioning. Overall cognitive score was tested with the early learning composite (ELC) of Mullen Scales of Early Learning (n = 19), and Full Scale IQ (FSIQ) of Wechsler Intelligence Scale for Children–Fourth Edition (n = 18). Results ELC was 85.7 ± 16.4, lower than the expected norm of 100, P = 0.004, and 6 survivors had moderate, and 3 severe delay, which is not greater than expected in the general population (P = 0.148). FSIQ was 99.6 ± 19.1, consistent with the expected norm of 100, P = 0.922, and 3 survivors had moderate and 2 severe delay, which is greater than expected (P = 0.048). Although ELC was lower than FSIQ (P = 0.024), within each testing group overall cognitive ability was not associated with participant age (ELC, P = 0.732; FSIQ, P = 0.909). Longer hospital stay was the only factor found to be consistently associated with a worse cognitive score across all participants in our cohort. Conclusions A high percentage of survivors with CDH have moderate to severe cognitive impairment suggesting that these subjects warrant early testing with implementation of therapeutic and educational interventions.

KW - Congenital diaphragmatic hernia

KW - Cross-sectional study

KW - Early learning composite score, ELC

KW - Full scale IQ, FSIQ

KW - Mullen Scales of Early Learning, MSEL

KW - Wechsler Intelligence Scale–Fourth Edition, WISC-IV

UR - http://www.scopus.com/inward/record.url?scp=84990943356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990943356&partnerID=8YFLogxK

U2 - 10.1016/j.jpedsurg.2016.05.011

DO - 10.1016/j.jpedsurg.2016.05.011

M3 - Article

C2 - 27519557

AN - SCOPUS:84990943356

VL - 51

SP - 1627

EP - 1634

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 10

ER -