Neurobiologic basis of nicotine addiction and psychostimulant abuse

A role for neurotensin?

Paul Fredrickson, Mona Boules, Siong C. Lin, Elliott Richelson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Addiction to psychostimulant drugs such as nicotine, amphetamine, and cocaine is a serious public health problem for which there is a paucity of accepted forms of pharmacotherapy. Nicotine dependence has become more frequently associated with psychiatric illness in recent decades, and patients who have schizophrenia are at highest risk and have the poorest prognosis for stopping their addiction. Possible mechanisms for this association include self-medication, with nicotine attenuating attentional deficits and negative symptoms. Neurotensin has been postulated to be an endogenous neuroleptic, and the performance of neurotensin analogues in animal models of addiction makes such compounds intriguing candidates for treatment of addiction in high-risk psychiatric populations.

Original languageEnglish (US)
Pages (from-to)737-751
Number of pages15
JournalPsychiatric Clinics of North America
Volume28
Issue number3 SPEC. ISS.
DOIs
StatePublished - Sep 2005

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Neurotensin
Nicotine
Psychiatry
Self Medication
Tobacco Use Disorder
Amphetamine
Cocaine
Antipsychotic Agents
Schizophrenia
Animal Models
Public Health
Drug Therapy
Pharmaceutical Preparations
Population
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Neurobiologic basis of nicotine addiction and psychostimulant abuse : A role for neurotensin? / Fredrickson, Paul; Boules, Mona; Lin, Siong C.; Richelson, Elliott.

In: Psychiatric Clinics of North America, Vol. 28, No. 3 SPEC. ISS., 09.2005, p. 737-751.

Research output: Contribution to journalArticle

Fredrickson, Paul ; Boules, Mona ; Lin, Siong C. ; Richelson, Elliott. / Neurobiologic basis of nicotine addiction and psychostimulant abuse : A role for neurotensin?. In: Psychiatric Clinics of North America. 2005 ; Vol. 28, No. 3 SPEC. ISS. pp. 737-751.
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