TY - JOUR
T1 - Neurobiologic basis of nicotine addiction and psychostimulant abuse
T2 - A role for neurotensin?
AU - Fredrickson, Paul
AU - Boules, Mona
AU - Lin, Siong Chi
AU - Richelson, Elliott
PY - 2005/9
Y1 - 2005/9
N2 - Addiction to psychostimulant drugs such as nicotine, amphetamine, and cocaine is a serious public health problem for which there is a paucity of accepted forms of pharmacotherapy. Nicotine dependence has become more frequently associated with psychiatric illness in recent decades, and patients who have schizophrenia are at highest risk and have the poorest prognosis for stopping their addiction. Possible mechanisms for this association include self-medication, with nicotine attenuating attentional deficits and negative symptoms. Neurotensin has been postulated to be an endogenous neuroleptic, and the performance of neurotensin analogues in animal models of addiction makes such compounds intriguing candidates for treatment of addiction in high-risk psychiatric populations.
AB - Addiction to psychostimulant drugs such as nicotine, amphetamine, and cocaine is a serious public health problem for which there is a paucity of accepted forms of pharmacotherapy. Nicotine dependence has become more frequently associated with psychiatric illness in recent decades, and patients who have schizophrenia are at highest risk and have the poorest prognosis for stopping their addiction. Possible mechanisms for this association include self-medication, with nicotine attenuating attentional deficits and negative symptoms. Neurotensin has been postulated to be an endogenous neuroleptic, and the performance of neurotensin analogues in animal models of addiction makes such compounds intriguing candidates for treatment of addiction in high-risk psychiatric populations.
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U2 - 10.1016/j.psc.2005.05.001
DO - 10.1016/j.psc.2005.05.001
M3 - Review article
C2 - 16122577
AN - SCOPUS:23944481933
SN - 0193-953X
VL - 28
SP - 737
EP - 751
JO - Psychiatric Clinics of North America
JF - Psychiatric Clinics of North America
IS - 3 SPEC. ISS.
ER -