Neural stem cell niches and homing: recruitment and integration into functional tissues.

Tomás Garzón-Muvdi, Alfredo Quiñones-Hinojosa

Research output: Contribution to journalReview article

Abstract

Considerable attention has focused on the study of neural stem cells (NSCs) as therapy for neurodegenerative diseases. The mammalian brain harbors NSCs throughout life mainly in the subventricular zone (SVZ) as well as the subgranular zone. NSCs in the SVZ are a specialized subpopulation of astrocytes that maintain contact with the ventricle and vascular structures. Components of the SVZ microenvironment, or niche, include intercellular interactions, extracellular matrix proteins, and soluble factors, all of which aid in NSC proliferation, self-renewal, and multipotentiality. Multiple studies demonstrate that endogenous neurogenesis responds to insults such as ischemic stroke, multiple sclerosis and other neurodegenerative diseases, and even brain tumors, supporting the existence of remarkable plasticity and significant regenerative potential in the mammalian brain. Further, in response to recruitment cues from damaged brain tissue NSCs not only "home" to sites of disease but also integrate into functional tissues and appear to acquire the morphological and physiological properties of neurons, astrocytes, and oligodendrocytes. In this review we focus on neurogenesis in the SVZ and on recruitment cues that promote homing and integration of NSCs to sites of disease in the brain. We also discuss animal models of important human neurodegenerative diseases in which transplantation of neural stem cells has been tested.

Original languageEnglish (US)
Pages (from-to)3-23
Number of pages21
JournalILAR journal / National Research Council, Institute of Laboratory Animal Resources
Volume51
Issue number1
StatePublished - 2009
Externally publishedYes

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Stem Cell Niche
Neural Stem Cells
Stem cells
stem cells
niches
Tissue
Lateral Ventricles
Brain
Neurodegenerative diseases
neurodegenerative diseases
Neurodegenerative Diseases
brain
neurogenesis
astrocytes
Neurogenesis
Astrocytes
Cues
central nervous system diseases
Extracellular Matrix Proteins
Oligodendroglia

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "Considerable attention has focused on the study of neural stem cells (NSCs) as therapy for neurodegenerative diseases. The mammalian brain harbors NSCs throughout life mainly in the subventricular zone (SVZ) as well as the subgranular zone. NSCs in the SVZ are a specialized subpopulation of astrocytes that maintain contact with the ventricle and vascular structures. Components of the SVZ microenvironment, or niche, include intercellular interactions, extracellular matrix proteins, and soluble factors, all of which aid in NSC proliferation, self-renewal, and multipotentiality. Multiple studies demonstrate that endogenous neurogenesis responds to insults such as ischemic stroke, multiple sclerosis and other neurodegenerative diseases, and even brain tumors, supporting the existence of remarkable plasticity and significant regenerative potential in the mammalian brain. Further, in response to recruitment cues from damaged brain tissue NSCs not only {"}home{"} to sites of disease but also integrate into functional tissues and appear to acquire the morphological and physiological properties of neurons, astrocytes, and oligodendrocytes. In this review we focus on neurogenesis in the SVZ and on recruitment cues that promote homing and integration of NSCs to sites of disease in the brain. We also discuss animal models of important human neurodegenerative diseases in which transplantation of neural stem cells has been tested.",
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