Neural misdirection in congenital ocular fibrosis syndrome

Implications and pathogenesis

Michael C Brodsky, S. C. Pollock, E. G. Buckley

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A child with congenital ocular fibrosis syndrome and oculocutaneous albinism displayed two distinct neural misdirection syndromes: synergistic divergence and Marcus Gunn jaw winking. This and other reported cases of misdirected innervation in patients with congenital fibrosis syndrome suggest that normal neuronal connections fail to become established early in development and that lack of innervation may underlie the pathologic features of the disorder. The prevailing concept of congenital fibrosis syndrome as a primary myopathy should be reconsidered.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalJournal of Pediatric Ophthalmology and Strabismus
Volume26
Issue number4
StatePublished - 1989
Externally publishedYes

Fingerprint

Oculocutaneous Albinism
Muscular Diseases
Congenital Fibrosis of the Extraocular Muscles
Marcus Gunn phenomenon

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health

Cite this

Neural misdirection in congenital ocular fibrosis syndrome : Implications and pathogenesis. / Brodsky, Michael C; Pollock, S. C.; Buckley, E. G.

In: Journal of Pediatric Ophthalmology and Strabismus, Vol. 26, No. 4, 1989, p. 159-161.

Research output: Contribution to journalArticle

@article{6ca1224a64304699b07ce2b6cc0c3b37,
title = "Neural misdirection in congenital ocular fibrosis syndrome: Implications and pathogenesis",
abstract = "A child with congenital ocular fibrosis syndrome and oculocutaneous albinism displayed two distinct neural misdirection syndromes: synergistic divergence and Marcus Gunn jaw winking. This and other reported cases of misdirected innervation in patients with congenital fibrosis syndrome suggest that normal neuronal connections fail to become established early in development and that lack of innervation may underlie the pathologic features of the disorder. The prevailing concept of congenital fibrosis syndrome as a primary myopathy should be reconsidered.",
author = "Brodsky, {Michael C} and Pollock, {S. C.} and Buckley, {E. G.}",
year = "1989",
language = "English (US)",
volume = "26",
pages = "159--161",
journal = "Journal of Pediatric Ophthalmology and Strabismus",
issn = "0191-3913",
publisher = "Slack Incorporated",
number = "4",

}

TY - JOUR

T1 - Neural misdirection in congenital ocular fibrosis syndrome

T2 - Implications and pathogenesis

AU - Brodsky, Michael C

AU - Pollock, S. C.

AU - Buckley, E. G.

PY - 1989

Y1 - 1989

N2 - A child with congenital ocular fibrosis syndrome and oculocutaneous albinism displayed two distinct neural misdirection syndromes: synergistic divergence and Marcus Gunn jaw winking. This and other reported cases of misdirected innervation in patients with congenital fibrosis syndrome suggest that normal neuronal connections fail to become established early in development and that lack of innervation may underlie the pathologic features of the disorder. The prevailing concept of congenital fibrosis syndrome as a primary myopathy should be reconsidered.

AB - A child with congenital ocular fibrosis syndrome and oculocutaneous albinism displayed two distinct neural misdirection syndromes: synergistic divergence and Marcus Gunn jaw winking. This and other reported cases of misdirected innervation in patients with congenital fibrosis syndrome suggest that normal neuronal connections fail to become established early in development and that lack of innervation may underlie the pathologic features of the disorder. The prevailing concept of congenital fibrosis syndrome as a primary myopathy should be reconsidered.

UR - http://www.scopus.com/inward/record.url?scp=0024400197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024400197&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 159

EP - 161

JO - Journal of Pediatric Ophthalmology and Strabismus

JF - Journal of Pediatric Ophthalmology and Strabismus

SN - 0191-3913

IS - 4

ER -