TY - JOUR
T1 - Neural isolation of the entire canine stomach in vivo
T2 - Effects on motility
AU - Van Lier Ribbink, J. A.
AU - Sarr, M. G.
AU - Tanaka, M.
PY - 1989
Y1 - 1989
N2 - This study was designed to determine the effects of transection of all extrinsic and enteric neural continuity to the entire stomach on motility patterns of the stomach and small intestine. Five dogs were subjected to a model of orthotopic autotransplantation of the stomach to achieve an in vivo, 'neurally isolated' stomach. Manometric catheters and serosal electrodes were implanted. A cyclic motor pattern occurred during fasting and was closely coordinated temporally with the migrating motor complex (MMC) in the small bowel. The period of the cyclic gastric motor activity did not differ from the period of the MMC in the small intestine [121 ± 8 vs. 124 ± 10 (means ± SE) min, P = 0.4], but the periods of both were greater than in control dogs (93 ± 5 min, P < 0.05). Tachygastria accounted for 36 ± 13% of fasting myoelectric activity in the neurally isolated dogs and for <1% in control dogs. Plasma concentration of motilin was greatest during the phase III-like gastric motor activity; exogenous motilin induced premature phase III-like activity in the stomach and small intestine. Feeding abolished the cyclic motor activity in the stomach and decreased plasma motilin concentration. These data suggest that hormonal factors, and not extrinsic or intrinsic neural continuity to the stomach, may control both the initiation of a cyclic interdigestive gastric motor pattern and its temporal coordination with motor patterns in the small intestine.
AB - This study was designed to determine the effects of transection of all extrinsic and enteric neural continuity to the entire stomach on motility patterns of the stomach and small intestine. Five dogs were subjected to a model of orthotopic autotransplantation of the stomach to achieve an in vivo, 'neurally isolated' stomach. Manometric catheters and serosal electrodes were implanted. A cyclic motor pattern occurred during fasting and was closely coordinated temporally with the migrating motor complex (MMC) in the small bowel. The period of the cyclic gastric motor activity did not differ from the period of the MMC in the small intestine [121 ± 8 vs. 124 ± 10 (means ± SE) min, P = 0.4], but the periods of both were greater than in control dogs (93 ± 5 min, P < 0.05). Tachygastria accounted for 36 ± 13% of fasting myoelectric activity in the neurally isolated dogs and for <1% in control dogs. Plasma concentration of motilin was greatest during the phase III-like gastric motor activity; exogenous motilin induced premature phase III-like activity in the stomach and small intestine. Feeding abolished the cyclic motor activity in the stomach and decreased plasma motilin concentration. These data suggest that hormonal factors, and not extrinsic or intrinsic neural continuity to the stomach, may control both the initiation of a cyclic interdigestive gastric motor pattern and its temporal coordination with motor patterns in the small intestine.
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M3 - Article
C2 - 2750907
AN - SCOPUS:0024369588
SN - 0002-9513
VL - 257
SP - 20/1
JO - American Journal of Physiology - Gastrointestinal and Liver Physiology
JF - American Journal of Physiology - Gastrointestinal and Liver Physiology
IS - 1
ER -