Neural control of skeletal muscle cholinesterase: A study using organ-cultured rat muscle

B. Davey, L. H. Younkin, Steven G Younkin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

It has been proposed that the influence of innervation on the cholinesterase activity (ChE) of skeletal muscle and on end-plate ChE in particular is mediated by trophic substance(s) moved by axonal transport and released from nerve. We have tested this hypothesis using rat extensor digitorum longus (e.d.l.) and diaphragm muscles denervated in vitro for several days and then maintained in organ culture to assay putative trophic substance(s). The findings provide strong evidence for the concept that the influence of innervation on the end-plate ChE of skeletal muscle is mediated by trophic substance(s) moved by axonal transport and released from nerve.

Original languageEnglish (US)
Pages (from-to)501-515
Number of pages15
JournalJournal of Physiology
VolumeVOL 289
StatePublished - 1979
Externally publishedYes

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Cholinesterases
Skeletal Muscle
Axonal Transport
Muscles
Organ Culture Techniques
Diaphragm

ASJC Scopus subject areas

  • Physiology

Cite this

Neural control of skeletal muscle cholinesterase : A study using organ-cultured rat muscle. / Davey, B.; Younkin, L. H.; Younkin, Steven G.

In: Journal of Physiology, Vol. VOL 289, 1979, p. 501-515.

Research output: Contribution to journalArticle

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