Neurabin contributes to hippocampal long-term potentiation and contextual fear memory

LongJun Wu, Ming Ren, Hansen Wang, Susan S. Kim, Xiaoyan Cao, Min Zhuo

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Neurabin is a scaffolding protein that interacts with actin and protein phosphatase-1. Highly enriched in the dendritic spine, neurabin is important for spine morphogenesis and synaptic formation. However, less is known about the role of neurabin in hippocampal plasticity and its possible effect on behavioral functions. Using neurabin knockout (KO) mice, here we studied the function of neurabin in hippocampal synaptic transmission, plasticity and behavioral memory. We demonstrated that neurabin KO mice showed a deficit in contextual fear memory but not auditory fear memory. Whole-cell patch clamp recordings in the hippocampal CA1 neurons showed that long-term potentiation (LTP) was significantly reduced, whereas long-term depression (LTD) was unaltered in neurabin KO mice. Moreover, increased AMPA receptor but not NMDA receptor-mediated synaptic transmission was found in neurabin KO mice, and is accompanied by decreased phosphorylation of GluR1 at the PKA site (Ser845) but no change at the CaMKII/PKC site (Ser831). Pre-condixioning with LTD induction rescued the following LTP in neurabin KO mice, suggesting the loss of LTP may be due to the saturated synaptic transmission. Our results indicate that neurabin regulates contextual fear memory and LTP in hippocampal CA1 pyramidal neurons. Copyright:

Original languageEnglish (US)
Article numbere1407
JournalPLoS One
Volume3
Issue number1
DOIs
StatePublished - Jan 9 2008
Externally publishedYes

Fingerprint

Long-Term Potentiation
fearfulness
Fear
synaptic transmission
Data storage equipment
mice
Knockout Mice
neurons
Synaptic Transmission
scaffolding proteins
phosphoprotein phosphatase
receptors
Neurons
morphogenesis
actin
Plasticity
phosphorylation
neurabin
Depression
Protein Phosphatase 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Neurabin contributes to hippocampal long-term potentiation and contextual fear memory. / Wu, LongJun; Ren, Ming; Wang, Hansen; Kim, Susan S.; Cao, Xiaoyan; Zhuo, Min.

In: PLoS One, Vol. 3, No. 1, e1407, 09.01.2008.

Research output: Contribution to journalArticle

Wu, LongJun ; Ren, Ming ; Wang, Hansen ; Kim, Susan S. ; Cao, Xiaoyan ; Zhuo, Min. / Neurabin contributes to hippocampal long-term potentiation and contextual fear memory. In: PLoS One. 2008 ; Vol. 3, No. 1.
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