Network systems biology for drug discovery

D. K. Arrell, A. Terzic

Research output: Contribution to journalReview articlepeer-review

146 Scopus citations

Abstract

Systems biology provides a platform for integrating multiple components and interactions underlying cell, organ, and organism processes in health and disease. Beyond traditional approaches focused on individual molecules or pathways, bioinformatic network analysis of high-throughput data sets offers an opportunity for integration of biological complexity and multilevel connectivity. Emerging applications in rational drug discovery range from targeting and modeling disease-corrupted networks to screening chemical or ligand libraries to identification/validation of drug-target interactions for improved efficacy and safety.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalClinical pharmacology and therapeutics
Volume88
Issue number1
DOIs
StatePublished - Jul 24 2010

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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