Nesiritide in acute decompensated heart failure: Current status and future perspectives

Selma F. Mohammed, Josef Korinek, Horng H. Chen, John C. Burnett, Margaret M. Redfield

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Acute decompensated heart failure (ADHF) is a growing public health problem with high mortality and costs. ADHF often, if not usually, occurs in the setting of cardiovascular and noncardiovascular comorbidities as well as advanced age. New insights provide support for the concept of heart failure as a state of deficiency of and/or resistance to endogenous B-type natriuretic peptide. The primary goals of ADHF therapy are to relieve symptoms and optimize volume status with minimal side effects. Few therapies are proven to effectively do so. Nesiritide is a balanced vasodilator with favorable neurohumoral effects and is superior to placebo in providing rapid symptom relief and to nitroglycerin in reducing filling pressures. Recent trials confirm a lack of renal toxicity at recommended doses. An adequately powered multinational mortality trial is underway. Nesiritide represents a proven therapy for normotensive/hypertensive ADHF patients with severe symptoms at rest.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalReviews in cardiovascular medicine
Volume9
Issue number3
StatePublished - Jun 1 2008

Keywords

  • Acute decompensated heart failure
  • B-type natriuretic peptide
  • Nesiritide
  • Renal function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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