Nerve growth factor rescue of cisplatin neurotoxicity is mediated through the high affinity receptor: Studies in PC12 cells and p75 null mouse dorsal root ganglia

Stephanie J. Fischer, Jewel L. Podratz, Anthony J. Windebank

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Nerve growth factor (NGF) rescues dorsal root ganglion neurons and PC12 cells from cisplatin-induced cell death. Two model systems were used to demonstrate that rescue is mediated through the high affinity NGF receptor. In dorsal root ganglion (DRG) neurons isolated from p75-/- and control mice, 20 ng/ml NGF completely prevented cisplatin-induced death. In PC12 cells, we overexpressed receptor chimeras between the tumor necrosis factor and NGF receptors. We demonstrated that activation of the intracellular domain of Trk A is responsible for the NGF rescue effect.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Volume308
Issue number1
DOIs
StatePublished - Jul 27 2001

Keywords

  • Dorsal root ganglia
  • Nerve growth factor

ASJC Scopus subject areas

  • Neuroscience(all)

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