Nerve growth factor rescue of cisplatin neurotoxicity is mediated through the high affinity receptor: Studies in PC12 cells and p75 null mouse dorsal root ganglia

Stephanie J. Fischer, Jewel L. Podratz, Anthony John Windebank

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Nerve growth factor (NGF) rescues dorsal root ganglion neurons and PC12 cells from cisplatin-induced cell death. Two model systems were used to demonstrate that rescue is mediated through the high affinity NGF receptor. In dorsal root ganglion (DRG) neurons isolated from p75-/- and control mice, 20 ng/ml NGF completely prevented cisplatin-induced death. In PC12 cells, we overexpressed receptor chimeras between the tumor necrosis factor and NGF receptors. We demonstrated that activation of the intracellular domain of Trk A is responsible for the NGF rescue effect.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Volume308
Issue number1
DOIs
StatePublished - Jul 27 2001

Fingerprint

PC12 Cells
Spinal Ganglia
Nerve Growth Factor
Cisplatin
Nerve Growth Factor Receptors
Neurons
Nerve Growth Factor Receptor
Cell Death
Tumor Necrosis Factor-alpha

Keywords

  • Dorsal root ganglia
  • Nerve growth factor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{e61d44ed2d0c416ab422567033157d0b,
title = "Nerve growth factor rescue of cisplatin neurotoxicity is mediated through the high affinity receptor: Studies in PC12 cells and p75 null mouse dorsal root ganglia",
abstract = "Nerve growth factor (NGF) rescues dorsal root ganglion neurons and PC12 cells from cisplatin-induced cell death. Two model systems were used to demonstrate that rescue is mediated through the high affinity NGF receptor. In dorsal root ganglion (DRG) neurons isolated from p75-/- and control mice, 20 ng/ml NGF completely prevented cisplatin-induced death. In PC12 cells, we overexpressed receptor chimeras between the tumor necrosis factor and NGF receptors. We demonstrated that activation of the intracellular domain of Trk A is responsible for the NGF rescue effect.",
keywords = "Dorsal root ganglia, Nerve growth factor",
author = "Fischer, {Stephanie J.} and Podratz, {Jewel L.} and Windebank, {Anthony John}",
year = "2001",
month = "7",
day = "27",
doi = "10.1016/S0304-3940(01)01956-5",
language = "English (US)",
volume = "308",
pages = "1--4",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Nerve growth factor rescue of cisplatin neurotoxicity is mediated through the high affinity receptor

T2 - Studies in PC12 cells and p75 null mouse dorsal root ganglia

AU - Fischer, Stephanie J.

AU - Podratz, Jewel L.

AU - Windebank, Anthony John

PY - 2001/7/27

Y1 - 2001/7/27

N2 - Nerve growth factor (NGF) rescues dorsal root ganglion neurons and PC12 cells from cisplatin-induced cell death. Two model systems were used to demonstrate that rescue is mediated through the high affinity NGF receptor. In dorsal root ganglion (DRG) neurons isolated from p75-/- and control mice, 20 ng/ml NGF completely prevented cisplatin-induced death. In PC12 cells, we overexpressed receptor chimeras between the tumor necrosis factor and NGF receptors. We demonstrated that activation of the intracellular domain of Trk A is responsible for the NGF rescue effect.

AB - Nerve growth factor (NGF) rescues dorsal root ganglion neurons and PC12 cells from cisplatin-induced cell death. Two model systems were used to demonstrate that rescue is mediated through the high affinity NGF receptor. In dorsal root ganglion (DRG) neurons isolated from p75-/- and control mice, 20 ng/ml NGF completely prevented cisplatin-induced death. In PC12 cells, we overexpressed receptor chimeras between the tumor necrosis factor and NGF receptors. We demonstrated that activation of the intracellular domain of Trk A is responsible for the NGF rescue effect.

KW - Dorsal root ganglia

KW - Nerve growth factor

UR - http://www.scopus.com/inward/record.url?scp=0035958820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035958820&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(01)01956-5

DO - 10.1016/S0304-3940(01)01956-5

M3 - Article

C2 - 11445271

AN - SCOPUS:0035958820

VL - 308

SP - 1

EP - 4

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -