Nerve endings of the wrist joint: A preliminary report of the dorsal radiocarpal ligament

Yu T. Lin, Richard A. Berger, Evelyn J. Berger, Kazunari Tomita, Jean Y. Jew, Chao Yang, Kai N. An

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

As part of an investigation of the articular nerve ending populations in the wrist joint capsule associated with the anterior and posterior interosseous nerves, this study addresses the nerve ending population in the dorsal radiocarpal ligament. The ligaments were harvested from four wrists of two fresh cadavers within 12 h of death. Tissues were fixed, cryostat sectioned, and processed for fluorescence immunohistochemistry using antibody to protein gene product 9.5 (PGP 9.5), a general or pan neuronal marker, and a secondary antibody conjugated to a fluorescent tag (Alexa Fluor 488). The sections were evaluated with a confocal laser microscope and an image analyzer. Labeled nerve endings were mapped, measured, and categorized. Type I (Ruffini-like ending), Type III (Golgi-like tendon organ) and Type IV (noncorpuscular) nerve endings could be identified in all four DRC ligaments, with Types I and IV dominating. These receptors were distributed primarily over the superficial two thirds of the ligament (>80%), and near the bony attachments (>70%). The dorsal radiocarpal ligament has a rich sensory innervation from the posterior interosseous nerve terminating in nerve endings located in the superficial two-thirds of the ligaments, primarily near bony attachment sites.

Original languageEnglish (US)
Pages (from-to)1225-1230
Number of pages6
JournalJournal of Orthopaedic Research
Volume24
Issue number6
DOIs
StatePublished - Jun 2006

Fingerprint

Wrist Joint
Nerve Endings
Ligaments
Joint Capsule
Mechanoreceptors
Antibodies
Wrist
Cadaver
Population
Lasers
Joints
Fluorescence
Immunohistochemistry

Keywords

  • Fluorescent immunohistochemistry
  • Ligament
  • Mechanoreceptor
  • Nerve ending
  • Wrist

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Lin, Y. T., Berger, R. A., Berger, E. J., Tomita, K., Jew, J. Y., Yang, C., & An, K. N. (2006). Nerve endings of the wrist joint: A preliminary report of the dorsal radiocarpal ligament. Journal of Orthopaedic Research, 24(6), 1225-1230. https://doi.org/10.1002/jor.20166

Nerve endings of the wrist joint : A preliminary report of the dorsal radiocarpal ligament. / Lin, Yu T.; Berger, Richard A.; Berger, Evelyn J.; Tomita, Kazunari; Jew, Jean Y.; Yang, Chao; An, Kai N.

In: Journal of Orthopaedic Research, Vol. 24, No. 6, 06.2006, p. 1225-1230.

Research output: Contribution to journalArticle

Lin, YT, Berger, RA, Berger, EJ, Tomita, K, Jew, JY, Yang, C & An, KN 2006, 'Nerve endings of the wrist joint: A preliminary report of the dorsal radiocarpal ligament', Journal of Orthopaedic Research, vol. 24, no. 6, pp. 1225-1230. https://doi.org/10.1002/jor.20166
Lin, Yu T. ; Berger, Richard A. ; Berger, Evelyn J. ; Tomita, Kazunari ; Jew, Jean Y. ; Yang, Chao ; An, Kai N. / Nerve endings of the wrist joint : A preliminary report of the dorsal radiocarpal ligament. In: Journal of Orthopaedic Research. 2006 ; Vol. 24, No. 6. pp. 1225-1230.
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