Neovascularization after ischemic nerve injury

Hitoshi Nukada; Peter James Dyck

doi:10.1016/0014-4886(86)90090-7

Neovascularization after ischemic nerve injury

Hitoshi Nukada, Peter James Dyck

Neurology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Because angioneogenesis is associated with wound repair, neovascularization may play an important role in regeneration after nerve injury. This hypothesis was tested in the present study in which the number and distribution of endoneurial capillaries were determined 6 weeks after ischemic nerve injury. The density of capillaries was increased in the central fascicular regions of the distal sciatic and proximal tibial nerves at sites of ischemic injury. This was accompanied by a decrease in intercapillary distance. Neovascularization may be a response to ischemia or a consequence of nerve degeneration or regeneration, the mechanisms of which are poorly understood.

Original language	English (US)
Pages (from-to)	391-397
Number of pages	7
Journal	Experimental Neurology
Volume	92
Issue number	2
DOIs	https://doi.org/10.1016/0014-4886(86)90090-7
State	Published - May 1986

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/0014-4886(86)90090-7

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title = "Neovascularization after ischemic nerve injury",

abstract = "Because angioneogenesis is associated with wound repair, neovascularization may play an important role in regeneration after nerve injury. This hypothesis was tested in the present study in which the number and distribution of endoneurial capillaries were determined 6 weeks after ischemic nerve injury. The density of capillaries was increased in the central fascicular regions of the distal sciatic and proximal tibial nerves at sites of ischemic injury. This was accompanied by a decrease in intercapillary distance. Neovascularization may be a response to ischemia or a consequence of nerve degeneration or regeneration, the mechanisms of which are poorly understood.",

author = "Hitoshi Nukada and Dyck, {Peter James}",

note = "Funding Information: Abbreviation: MICD-minimum intercapillary distance. {\textquoteright} This investigation was supported in part by a Peripheral Neuropathy Clinical Center Grant from the National Institutes of Health (NS14304). a Center Grant from the Muscular Dystrophy Association, and a grant from the New Zealand Neurological Foundation. Please address corre- spondence to Dr. H. Nukada, Dept. of Medicine, Univ. of Otago Medical School, P.O. Box 9 13, Dunedin, New Zealand.",

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PY - 1986/5

Y1 - 1986/5

N2 - Because angioneogenesis is associated with wound repair, neovascularization may play an important role in regeneration after nerve injury. This hypothesis was tested in the present study in which the number and distribution of endoneurial capillaries were determined 6 weeks after ischemic nerve injury. The density of capillaries was increased in the central fascicular regions of the distal sciatic and proximal tibial nerves at sites of ischemic injury. This was accompanied by a decrease in intercapillary distance. Neovascularization may be a response to ischemia or a consequence of nerve degeneration or regeneration, the mechanisms of which are poorly understood.

AB - Because angioneogenesis is associated with wound repair, neovascularization may play an important role in regeneration after nerve injury. This hypothesis was tested in the present study in which the number and distribution of endoneurial capillaries were determined 6 weeks after ischemic nerve injury. The density of capillaries was increased in the central fascicular regions of the distal sciatic and proximal tibial nerves at sites of ischemic injury. This was accompanied by a decrease in intercapillary distance. Neovascularization may be a response to ischemia or a consequence of nerve degeneration or regeneration, the mechanisms of which are poorly understood.

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Neovascularization after ischemic nerve injury

Abstract

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