Neoplastic plasma cell aberrant antigen expression patterns and their association with genetic abnormalities

Mohamed E. Salama, Shouying Du, Olga Efimova, Nahla M. Heikal, Erik Wendlandt, Reha M. Toydemir, Sarah South, Sherrie L. Perkins, Jerry W. Hussong, Fenghuang Zhan

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Little is known about aberrant antigen expression patterns and their association with cytogenetic aberrations in multiple myeloma (MM). We examined the correlation between flow cytometry and florescence in situ hybridization (FISH) in 167 marrow specimens with MM. Gene expression profiling of CD56, CD117, CD52 and CD20 mRNA in plasma cells (PCs) from patients treated on Total Therapy 2 and Total Therapy 3 trials were also evaluated. Higher expression of CD56 and CD117 was associated with hyperdiploidy. High CD52 mRNA expression was associated with c-MAF and FGFR3 subgroups. Higher expression of CD56 mRNA, but lower Kit expression, were noted in association with FGFR3. In contrast, the c-MAF subgroup showed high Kit expression but lacked NCAM mRNA expression. CKS1B amplification showed positive correlation with CD52 (p = 0.0065) but negative correlation with CD20 (p = 0.0207). These findings indicate that phenotypic differences in MM are associated with distinct genetic subgroups, which potentially has important diagnostic and prognostic value.

Original languageEnglish (US)
Pages (from-to)426-433
Number of pages8
JournalLeukemia and Lymphoma
Volume56
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • Cytogenetics
  • Molecular genetics
  • Myeloma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Salama, M. E., Du, S., Efimova, O., Heikal, N. M., Wendlandt, E., Toydemir, R. M., South, S., Perkins, S. L., Hussong, J. W., & Zhan, F. (2015). Neoplastic plasma cell aberrant antigen expression patterns and their association with genetic abnormalities. Leukemia and Lymphoma, 56(2), 426-433. https://doi.org/10.3109/10428194.2014.931951