Neoplastic lumbosacral radiculoplexopathy in prostate cancer by direct perineural spread: An unusual entity

Shafeeq S. Ladha, Robert J. Spinner, Guillermo A. Suarez, Kimberly K. Amrami, P. James B Dyck

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Neoplastic lumbosacral plexopathy occurs with some abdominal and pelvic malignancies. Patients present with severe pain radiating from the low back down to the lower extremities, and this progresses to weakness. Neoplastic lumbosacral plexopathy is virtually always associated with known malignancy or obvious pelvic metastatic disease. Uncommonly, prostate cancer can present as a lumbosacral plexopathy occurring through direct pelvic spread. We describe two cases of lumbosacral radiculoplexopathy from infiltrative prostate cancer without evidence of other pelvic or extraprostatic spread. The probable etiology of tumor spreading along prostatic nerves into the lumbosacral plexus (i.e., perineural spread) is discussed as are the potential mechanisms for this unusual mode of cancer dissemination.

Original languageEnglish (US)
Pages (from-to)659-665
Number of pages7
JournalMuscle and Nerve
Volume34
Issue number5
DOIs
StatePublished - Nov 2006

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Prostatic Neoplasms
Neoplasms
Lumbosacral Plexus
Low Back Pain
Lower Extremity

Keywords

  • Carcinomatous neuropathy
  • Lumbosacral plexopathy
  • Lumbosacral radiculoplexopathy
  • Perineural spread
  • Prostate cancer

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neoplastic lumbosacral radiculoplexopathy in prostate cancer by direct perineural spread : An unusual entity. / Ladha, Shafeeq S.; Spinner, Robert J.; Suarez, Guillermo A.; Amrami, Kimberly K.; Dyck, P. James B.

In: Muscle and Nerve, Vol. 34, No. 5, 11.2006, p. 659-665.

Research output: Contribution to journalArticle

Ladha, Shafeeq S. ; Spinner, Robert J. ; Suarez, Guillermo A. ; Amrami, Kimberly K. ; Dyck, P. James B. / Neoplastic lumbosacral radiculoplexopathy in prostate cancer by direct perineural spread : An unusual entity. In: Muscle and Nerve. 2006 ; Vol. 34, No. 5. pp. 659-665.
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