Nelfinavir monotherapy increases naïve T-cell numbers in HIV-negative healthy young adults

Stacey Rizza, Eric George Tangalos, Mark D. McClees, Michael A. Strausbauch, Paul V. Targonski, David J. McKean, Peter J. Wettstein, Andrew David Badley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although patients treated with HIV protease inhibitor (PI) containing regimens manifest increases in naïve T cell number, it is unclear whether this is due to reduction in viral replication or a direct drug effect. We questioned whether Nelfinavir monotherapy directly impacted naïve T-cell number in HIV-negative individuals. HIV-negative volunteers received Nelfinavir, 1250 mg orally, BID for 3 weeks, and T-cell receptor recombination excision circles (TREC) content in peripheral blood were assessed. Whereas TREC copies did not change over 3 weeks in untreated controls, TREC copies/copies CCR5 increased following Nelfinavir monotherapy in 8 patients (p<0.02), and did not change in 7 patients (p=NS). Those patients who responded were younger than those who did not with a median age of 55 years for responders and 71 years for non-responders (p<0.03). The increase in TREC was most pronounced in those patients less than 40-years old (p<0.01). Moreover, the patients who did not increase TREC levels were more likely to have suffered a medical illness previously shown to reduce thymic function. In HIV-negative patients, monotherapy with the HIV PI Nelfinavir for 21 days increases TREC-positive naïve T cell number, particularly in individuals who are healthy and young.

Original languageEnglish (US)
Pages (from-to)1605-1609
Number of pages5
JournalFrontiers in Bioscience
Volume13
Issue number5
DOIs
StatePublished - 2008

Fingerprint

Nelfinavir
T-cells
T-Cell Antigen Receptor
Young Adult
Genetic Recombination
Cell Count
HIV
T-Lymphocytes
HIV Protease Inhibitors
Blood
Volunteers
Pharmaceutical Preparations

Keywords

  • Age
  • HIV protease inhibitors
  • Nelfinavir
  • TREC

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology
  • Medicine(all)

Cite this

Nelfinavir monotherapy increases naïve T-cell numbers in HIV-negative healthy young adults. / Rizza, Stacey; Tangalos, Eric George; McClees, Mark D.; Strausbauch, Michael A.; Targonski, Paul V.; McKean, David J.; Wettstein, Peter J.; Badley, Andrew David.

In: Frontiers in Bioscience, Vol. 13, No. 5, 2008, p. 1605-1609.

Research output: Contribution to journalArticle

Rizza, Stacey ; Tangalos, Eric George ; McClees, Mark D. ; Strausbauch, Michael A. ; Targonski, Paul V. ; McKean, David J. ; Wettstein, Peter J. ; Badley, Andrew David. / Nelfinavir monotherapy increases naïve T-cell numbers in HIV-negative healthy young adults. In: Frontiers in Bioscience. 2008 ; Vol. 13, No. 5. pp. 1605-1609.
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