Negatively selected H-2(bml) and H-2b T cells stimulated with vaccinia virus completely discriminate between mutant and wild-type H-2K alleles

P. C. Doherty, J. R. Bennink, P. J. Wettstein

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Lymphocyte populations from B6.C-H2(bml)(K(bml)Db) mutant mice cannot, after both in vivo and in vitro negative selection for alloreactivity, be induced to recognize vaccinia virus presented in the context of H-2Kb. This finding may mean that the T cell receptor(s) expresses a component that is very specific for a particular 'active site' on the self-H-2 molecule. Alternatively, (if recognition is directed at a virus-H-2 complex) the more similar 2 H-2 molecules are, the more likely it may be that precursor thymocytes in the mutant with the capacity to bind H-2Kb + vaccinia virus may be deleted during ontogeny as a result of cross-reaction with H-2K(bml) + endogenous antigen.

Original languageEnglish (US)
Pages (from-to)131-133
Number of pages3
JournalJournal of Immunology
Volume126
Issue number1
StatePublished - 1981
Externally publishedYes

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Vaccinia virus
Alleles
T-Lymphocytes
Cross Reactions
Thymocytes
T-Cell Antigen Receptor
Catalytic Domain
Lymphocytes
Viruses
Antigens
Population
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

Negatively selected H-2(bml) and H-2b T cells stimulated with vaccinia virus completely discriminate between mutant and wild-type H-2K alleles. / Doherty, P. C.; Bennink, J. R.; Wettstein, P. J.

In: Journal of Immunology, Vol. 126, No. 1, 1981, p. 131-133.

Research output: Contribution to journalArticle

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abstract = "Lymphocyte populations from B6.C-H2(bml)(K(bml)Db) mutant mice cannot, after both in vivo and in vitro negative selection for alloreactivity, be induced to recognize vaccinia virus presented in the context of H-2Kb. This finding may mean that the T cell receptor(s) expresses a component that is very specific for a particular 'active site' on the self-H-2 molecule. Alternatively, (if recognition is directed at a virus-H-2 complex) the more similar 2 H-2 molecules are, the more likely it may be that precursor thymocytes in the mutant with the capacity to bind H-2Kb + vaccinia virus may be deleted during ontogeny as a result of cross-reaction with H-2K(bml) + endogenous antigen.",
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