NEDA treatment target? No evident disease activity as an actionable outcome in practice

Research output: Contribution to journalReview article

10 Scopus citations


“No evident disease activity” (NEDA) is a proposed measure of disease activity-free status in multiple sclerosis (MS) that is typically defined as absence of relapses, disability progression, and MRI activity over a defined time period. NEDA is increasingly reported in randomized controlled trials of MS disease modifying therapies where it has some perceived advantages over outcomes such as annualized relapse rate. NEDA has also been proposed as a treatment goal in clinical care. At this point, the long-term implications of early NEDA remain largely unknown. We review current NEDA definitions, use in clinical trials, and its prospects for routine use as an actionable treatment target in clinical practice.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalJournal of the Neurological Sciences
StatePublished - Dec 15 2017



  • Disease modifying therapy
  • Multiple sclerosis
  • No evident disease activity
  • Outcome measures
  • Treatment target

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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