Necrotizing myopathy with pipestem capillaries, microvascular deposition of the complement membrane attack complex (MAC), and minimal cellular infiltration

Alison M. Emslie-Smith, Andrew G. Engel

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Three adult patients, two with undifferentiated connective tissue disease and one with carcinoma, had a distinctive pathologic reaction pattern consisting of necrotizing myopathy, minimal cellular infiltration, and a microangiopathy with thick “pipestem” vessels and microvascular deposits of complement membrane attack complex. Quantitative analysis revealed focal capillary depletion. This pattern represents an immune-mediated microangiopathy and is distinct from that observed in other inflammatory myopathies.

Original languageEnglish (US)
Pages (from-to)936-939
Number of pages4
JournalNeurology
Volume41
Issue number6
DOIs
StatePublished - Jun 1991

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Necrotizing myopathy with pipestem capillaries, microvascular deposition of the complement membrane attack complex (MAC), and minimal cellular infiltration'. Together they form a unique fingerprint.

  • Cite this