Necrosectomy

Michael G. Sarr, Waldemar Uhl, Oliver Strobel, Markus W. Buchler, Carlos Fernández-Del Castillo, Gregory G. Tsiotos, C. Ross Carter, Clement W. Imrie

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Severe acute pancreatitis remains a life-threatening disease. The first phase (about 10-14 days) is characterized by formation of pancreatic and peripancreatic necrosis and development of a systemic inflammatory response syndrome. This systemic response to the pancreatic inflammation/necrosis causes early organ failure that necessitates intensive care therapy. In the second phase (after 2 weeks), the leading cause of morbidity and mortality is superinfection of necrosis with development of septic multiple organ failure. In the last 2 decades, treatment has evolved considerably, and with improved intensive care management, there is a worldwide trend toward a more conservative strategy with operative intervention initiated primarily because of the local and systemic manifestations of infected necrosis and less so for sterile necrosis. However, today, septic complications caused by pancreatic infection account for 80% of the mortality, and infected necrosis therefore usually remains an absolute indication for same form of invasive intervention.

Original languageEnglish (US)
Title of host publicationAtlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery
PublisherSpringer Berlin Heidelberg
Pages893-915
Number of pages23
ISBN (Print)9783540200048
DOIs
StatePublished - 2007

Fingerprint

Necrosis
Critical Care
Systemic Inflammatory Response Syndrome
Superinfection
Multiple Organ Failure
Mortality
Pancreatitis
Inflammation
Morbidity
Therapeutics
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sarr, M. G., Uhl, W., Strobel, O., Buchler, M. W., Fernández-Del Castillo, C., Tsiotos, G. G., ... Imrie, C. W. (2007). Necrosectomy. In Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery (pp. 893-915). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-68866-2_89

Necrosectomy. / Sarr, Michael G.; Uhl, Waldemar; Strobel, Oliver; Buchler, Markus W.; Fernández-Del Castillo, Carlos; Tsiotos, Gregory G.; Carter, C. Ross; Imrie, Clement W.

Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery. Springer Berlin Heidelberg, 2007. p. 893-915.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sarr, MG, Uhl, W, Strobel, O, Buchler, MW, Fernández-Del Castillo, C, Tsiotos, GG, Carter, CR & Imrie, CW 2007, Necrosectomy. in Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery. Springer Berlin Heidelberg, pp. 893-915. https://doi.org/10.1007/978-3-540-68866-2_89
Sarr MG, Uhl W, Strobel O, Buchler MW, Fernández-Del Castillo C, Tsiotos GG et al. Necrosectomy. In Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery. Springer Berlin Heidelberg. 2007. p. 893-915 https://doi.org/10.1007/978-3-540-68866-2_89
Sarr, Michael G. ; Uhl, Waldemar ; Strobel, Oliver ; Buchler, Markus W. ; Fernández-Del Castillo, Carlos ; Tsiotos, Gregory G. ; Carter, C. Ross ; Imrie, Clement W. / Necrosectomy. Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery. Springer Berlin Heidelberg, 2007. pp. 893-915
@inbook{c0aef779f8ec4dde914dd315f35b3e34,
title = "Necrosectomy",
abstract = "Severe acute pancreatitis remains a life-threatening disease. The first phase (about 10-14 days) is characterized by formation of pancreatic and peripancreatic necrosis and development of a systemic inflammatory response syndrome. This systemic response to the pancreatic inflammation/necrosis causes early organ failure that necessitates intensive care therapy. In the second phase (after 2 weeks), the leading cause of morbidity and mortality is superinfection of necrosis with development of septic multiple organ failure. In the last 2 decades, treatment has evolved considerably, and with improved intensive care management, there is a worldwide trend toward a more conservative strategy with operative intervention initiated primarily because of the local and systemic manifestations of infected necrosis and less so for sterile necrosis. However, today, septic complications caused by pancreatic infection account for 80{\%} of the mortality, and infected necrosis therefore usually remains an absolute indication for same form of invasive intervention.",
author = "Sarr, {Michael G.} and Waldemar Uhl and Oliver Strobel and Buchler, {Markus W.} and {Fern{\'a}ndez-Del Castillo}, Carlos and Tsiotos, {Gregory G.} and Carter, {C. Ross} and Imrie, {Clement W.}",
year = "2007",
doi = "10.1007/978-3-540-68866-2_89",
language = "English (US)",
isbn = "9783540200048",
pages = "893--915",
booktitle = "Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery",
publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - Necrosectomy

AU - Sarr, Michael G.

AU - Uhl, Waldemar

AU - Strobel, Oliver

AU - Buchler, Markus W.

AU - Fernández-Del Castillo, Carlos

AU - Tsiotos, Gregory G.

AU - Carter, C. Ross

AU - Imrie, Clement W.

PY - 2007

Y1 - 2007

N2 - Severe acute pancreatitis remains a life-threatening disease. The first phase (about 10-14 days) is characterized by formation of pancreatic and peripancreatic necrosis and development of a systemic inflammatory response syndrome. This systemic response to the pancreatic inflammation/necrosis causes early organ failure that necessitates intensive care therapy. In the second phase (after 2 weeks), the leading cause of morbidity and mortality is superinfection of necrosis with development of septic multiple organ failure. In the last 2 decades, treatment has evolved considerably, and with improved intensive care management, there is a worldwide trend toward a more conservative strategy with operative intervention initiated primarily because of the local and systemic manifestations of infected necrosis and less so for sterile necrosis. However, today, septic complications caused by pancreatic infection account for 80% of the mortality, and infected necrosis therefore usually remains an absolute indication for same form of invasive intervention.

AB - Severe acute pancreatitis remains a life-threatening disease. The first phase (about 10-14 days) is characterized by formation of pancreatic and peripancreatic necrosis and development of a systemic inflammatory response syndrome. This systemic response to the pancreatic inflammation/necrosis causes early organ failure that necessitates intensive care therapy. In the second phase (after 2 weeks), the leading cause of morbidity and mortality is superinfection of necrosis with development of septic multiple organ failure. In the last 2 decades, treatment has evolved considerably, and with improved intensive care management, there is a worldwide trend toward a more conservative strategy with operative intervention initiated primarily because of the local and systemic manifestations of infected necrosis and less so for sterile necrosis. However, today, septic complications caused by pancreatic infection account for 80% of the mortality, and infected necrosis therefore usually remains an absolute indication for same form of invasive intervention.

UR - http://www.scopus.com/inward/record.url?scp=84857503731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857503731&partnerID=8YFLogxK

U2 - 10.1007/978-3-540-68866-2_89

DO - 10.1007/978-3-540-68866-2_89

M3 - Chapter

AN - SCOPUS:84857503731

SN - 9783540200048

SP - 893

EP - 915

BT - Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery

PB - Springer Berlin Heidelberg

ER -