TY - CHAP
T1 - Necrosectomy
AU - Sarr, Michael G.
AU - Uhl, Waldemar
AU - Strobel, Oliver
AU - Buchler, Markus W.
AU - Fernández-Del Castillo, Carlos
AU - Tsiotos, Gregory G.
AU - Carter, C. Ross
AU - Imrie, Clement W.
PY - 2007
Y1 - 2007
N2 - Severe acute pancreatitis remains a life-threatening disease. The first phase (about 10-14 days) is characterized by formation of pancreatic and peripancreatic necrosis and development of a systemic inflammatory response syndrome. This systemic response to the pancreatic inflammation/necrosis causes early organ failure that necessitates intensive care therapy. In the second phase (after 2 weeks), the leading cause of morbidity and mortality is superinfection of necrosis with development of septic multiple organ failure. In the last 2 decades, treatment has evolved considerably, and with improved intensive care management, there is a worldwide trend toward a more conservative strategy with operative intervention initiated primarily because of the local and systemic manifestations of infected necrosis and less so for sterile necrosis. However, today, septic complications caused by pancreatic infection account for 80% of the mortality, and infected necrosis therefore usually remains an absolute indication for same form of invasive intervention.
AB - Severe acute pancreatitis remains a life-threatening disease. The first phase (about 10-14 days) is characterized by formation of pancreatic and peripancreatic necrosis and development of a systemic inflammatory response syndrome. This systemic response to the pancreatic inflammation/necrosis causes early organ failure that necessitates intensive care therapy. In the second phase (after 2 weeks), the leading cause of morbidity and mortality is superinfection of necrosis with development of septic multiple organ failure. In the last 2 decades, treatment has evolved considerably, and with improved intensive care management, there is a worldwide trend toward a more conservative strategy with operative intervention initiated primarily because of the local and systemic manifestations of infected necrosis and less so for sterile necrosis. However, today, septic complications caused by pancreatic infection account for 80% of the mortality, and infected necrosis therefore usually remains an absolute indication for same form of invasive intervention.
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U2 - 10.1007/978-3-540-68866-2_89
DO - 10.1007/978-3-540-68866-2_89
M3 - Chapter
AN - SCOPUS:84857503731
SN - 9783540200048
SP - 893
EP - 915
BT - Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery
PB - Springer Berlin Heidelberg
ER -