Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

Jeroen S. Goede, Benjamin Misselwitz, Christian Taverna, Urs Schanz, Angela Dispenzieri, Yvonne Hummel, Ralph M. Trüeb, Jörg Fehr

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalAnnals of hematology
Volume86
Issue number4
DOIs
StatePublished - Apr 2007

Keywords

  • Autologous transplantation
  • Blindness
  • Hematopoieticstem cell transplantation
  • Necrobioticxanthogranuloma
  • Paraprotein

ASJC Scopus subject areas

  • Hematology

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    Goede, J. S., Misselwitz, B., Taverna, C., Schanz, U., Dispenzieri, A., Hummel, Y., Trüeb, R. M., & Fehr, J. (2007). Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation. Annals of hematology, 86(4), 303-306. https://doi.org/10.1007/s00277-006-0231-0