Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

Jeroen S. Goede; Benjamin Misselwitz; Christian Taverna; Urs Schanz; Angela Dispenzieri; Yvonne Hummel; Ralph M. Trüeb; Jörg Fehr

doi:10.1007/s00277-006-0231-0

Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

Jeroen S. Goede, Benjamin Misselwitz, Christian Taverna, Urs Schanz, Angela Dispenzieri, Yvonne Hummel, Ralph M. Trüeb, Jörg Fehr

Hematology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.

Original language	English (US)
Pages (from-to)	303-306
Number of pages	4
Journal	Annals of hematology
Volume	86
Issue number	4
DOIs	https://doi.org/10.1007/s00277-006-0231-0
State	Published - Apr 2007

Keywords

Autologous transplantation
Blindness
Hematopoieticstem cell transplantation
Necrobioticxanthogranuloma
Paraprotein

ASJC Scopus subject areas

Hematology

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10.1007/s00277-006-0231-0

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title = "Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation",

abstract = "Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.",

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T1 - Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

AU - Goede, Jeroen S.

AU - Misselwitz, Benjamin

AU - Taverna, Christian

AU - Schanz, Urs

AU - Dispenzieri, Angela

AU - Hummel, Yvonne

AU - Trüeb, Ralph M.

AU - Fehr, Jörg

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AB - Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.

KW - Autologous transplantation

KW - Blindness

KW - Hematopoieticstem cell transplantation

KW - Necrobioticxanthogranuloma

KW - Paraprotein

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Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

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