Nearly identical near-haploid karyotype in a peritoneal mesothelioma and a retroperitoneal malignant peripheral nerve sheath tumor

William R. Sukov, Rhett P. Ketterling, Sainan Wei, Kristin Monaghan, Paul Blunden, Paul Mazzara, Ravi Raghavan, Andre M. Oliviera, Anne E. Wiktor, Gary L. Keeney, Daniel L. Van Dyke

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The presence of a near-haploid karyotype is a rare finding in human malignancies, most frequently occurring in acute leukemia. In solid tumors, a near-haploid karyotype has been reported in fewer than 40 cases. We report two nearly identical near-haploid karyotypes from two distinctly different tumor types. The first case is a biphasic malignant mesothelioma from a 53-year-old white woman forming a large retroperitoneal mass. Cytogenetic evaluation revealed a primary hyperdiploid cell population as well as near-haploid and hypertetraploid populations with an overall karyotype of 27,XX,i(5)(p10),+7,add(15)(p11.2),+dic(1;20)(p13;p13)[2]/54,idemx2[90]/101-108,idemx4[19]. The second case is a large pelvic mass from a 48-year-old man. Histologic examination identified a malignant peripheral nerve sheath tumor displaying a karyotype of 26,X,+i(5)(p10),+7,der(15)t(1;15)(q12;p12),+20[5]/52,idemx2[20]. Herein we discuss the potential relationship between these two disparate neoplasms with nearly identical near-haploid karyotypes and present a literature review.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume202
Issue number2
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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