Nature of gonadotropin-releasing hormone self-priming of luteinizing hormone secretion during the normal menstrual cycle

Michael J. Sollenberger, Elisabeth C. Carlsen, Robert A. Booth, Michael L. Johnson, Johannes D Veldhuis, William S. Evans

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

To investigate further the nature of the gonadotropin-releasing hormone self-priming effect on luteinizing hormone release, we administered two submaximal doses of gonadotropin-releasing hormone 2 hours apart to women at three stages of the menstrual cycle and analyzed the resultant luteinizing hormone secretory episodes with deconvolution analysis. When the characteristics of the secretory episodes associated with the second gonadotropin-releasing hormone challenge were compared with those associated with the first, both an enhanced maximal secretory rate and mass of luteinizing hormone secreted was demonstrable at each phase of the cycle. No differences in the luteinizing hormone secretory event half-duration were detected when the responses to the first and second gonadotropin-releasing hormone doses were compared. These data confirm the gonadal hormone milieu-associated self-priming effect of gonadotropin-releasing hormone on luteinizing hormone release and indicate that it is the rate with which luteinizing hormone molecules are discharged from the pituitary gland, rather than the duration of the secretory episode itself, that provides for the self-priming effect.

Original languageEnglish (US)
Pages (from-to)1529-1534
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume163
Issue number5 PART 1
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • deconvolution analysis
  • GnRH self-priming

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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