TY - JOUR
T1 - Nature of gonadotropin-releasing hormone self-priming of luteinizing hormone secretion during the normal menstrual cycle
AU - Sollenberger, Michael J.
AU - Carlsen, Elisabeth C.
AU - Booth, Robert A.
AU - Johnson, Michael L.
AU - Veldhuis, Johannes D.
AU - Evans, William S.
PY - 1990/11
Y1 - 1990/11
N2 - To investigate further the nature of the gonadotropin-releasing hormone self-priming effect on luteinizing hormone release, we administered two submaximal doses of gonadotropin-releasing hormone 2 hours apart to women at three stages of the menstrual cycle and analyzed the resultant luteinizing hormone secretory episodes with deconvolution analysis. When the characteristics of the secretory episodes associated with the second gonadotropin-releasing hormone challenge were compared with those associated with the first, both an enhanced maximal secretory rate and mass of luteinizing hormone secreted was demonstrable at each phase of the cycle. No differences in the luteinizing hormone secretory event half-duration were detected when the responses to the first and second gonadotropin-releasing hormone doses were compared. These data confirm the gonadal hormone milieu-associated self-priming effect of gonadotropin-releasing hormone on luteinizing hormone release and indicate that it is the rate with which luteinizing hormone molecules are discharged from the pituitary gland, rather than the duration of the secretory episode itself, that provides for the self-priming effect.
AB - To investigate further the nature of the gonadotropin-releasing hormone self-priming effect on luteinizing hormone release, we administered two submaximal doses of gonadotropin-releasing hormone 2 hours apart to women at three stages of the menstrual cycle and analyzed the resultant luteinizing hormone secretory episodes with deconvolution analysis. When the characteristics of the secretory episodes associated with the second gonadotropin-releasing hormone challenge were compared with those associated with the first, both an enhanced maximal secretory rate and mass of luteinizing hormone secreted was demonstrable at each phase of the cycle. No differences in the luteinizing hormone secretory event half-duration were detected when the responses to the first and second gonadotropin-releasing hormone doses were compared. These data confirm the gonadal hormone milieu-associated self-priming effect of gonadotropin-releasing hormone on luteinizing hormone release and indicate that it is the rate with which luteinizing hormone molecules are discharged from the pituitary gland, rather than the duration of the secretory episode itself, that provides for the self-priming effect.
KW - GnRH self-priming
KW - deconvolution analysis
UR - http://www.scopus.com/inward/record.url?scp=0025204193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025204193&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(90)90620-M
DO - 10.1016/0002-9378(90)90620-M
M3 - Article
C2 - 2240102
AN - SCOPUS:0025204193
SN - 0002-9378
VL - 163
SP - 1529
EP - 1534
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 5 PART 1
ER -