Nature of altered growth hormone secretion in hyperthyroidism

Ali Iranmanesh, German Lizarralde, Michael L. Johnson, Johannes D Veldhuis

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Hyperthyroidism is accompanied by various neuroendocrine regulatory disturbances that affect not only the thyrotropic, but also the gonadotropic, corticotropic, and somatotropic axes. To examine the nature of alterations in neuroendocrine control mechanisms that direct the somatotropic axis in hyperthyroidism, we have applied a novel deconvolution technique designed to estimate the number, amplitude, and mass of significant underlying GH secretory events after the influence of GH metabolic clearance has been removed mathematically. To this end, blood was sampled at 10-min intervals for 24 h in seven hyperthyroid and seven age-matched euthyroid men. The subsequent GH time series were assayed by immunoradiometric assay (sensitivity, 0.08 ng/mL) and submitted to quantitative deconvolution analysis. We found that hyperthyroid compared to euthyroid men 1) had significantly more GH secretory bursts per 24 h (viz. 15 ± 1.0 us. 10 ± 1.1; P = 0.017); 2) secreted 3 times as much GH per burst (3.7 ± 0.80 vs. 1.3 ± 0.42 ng/mL distribution vol; P = 0.013); 3) achieved a maximal rate of GH secretion in each burst 2.3-fold higher than that in control men (0.14 ± 0.028 vs. 0.060 ± 0.015 ng/mL·min; P = 0.017); and 4) had 3.7-fold higher 24-h endogenous GH production rates (P < 0.01). Neither hyperthyroid nor euthyroid men had significant interburst (tonic) GH secretion. We conclude that the somatotropic axis in hyperthyroid men is marked by a higher frequency of spontaneous GH secretory bursts, a higher rate of maximal GH secretion attained per burst, and a larger mass of GH released per burst. These neuroregulatory disturbances result in a nearly 4-fold increase in the 24-h production rate of GH in thyrotoxicosis.

Original languageEnglish (US)
Pages (from-to)108-115
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume72
Issue number1
StatePublished - Jan 1991
Externally publishedYes

Fingerprint

Deconvolution
Hyperthyroidism
Growth Hormone
Time series
Assays
Blood
Immunoradiometric Assay
Thyrotoxicosis

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Iranmanesh, A., Lizarralde, G., Johnson, M. L., & Veldhuis, J. D. (1991). Nature of altered growth hormone secretion in hyperthyroidism. Journal of Clinical Endocrinology and Metabolism, 72(1), 108-115.

Nature of altered growth hormone secretion in hyperthyroidism. / Iranmanesh, Ali; Lizarralde, German; Johnson, Michael L.; Veldhuis, Johannes D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 72, No. 1, 01.1991, p. 108-115.

Research output: Contribution to journalArticle

Iranmanesh, A, Lizarralde, G, Johnson, ML & Veldhuis, JD 1991, 'Nature of altered growth hormone secretion in hyperthyroidism', Journal of Clinical Endocrinology and Metabolism, vol. 72, no. 1, pp. 108-115.
Iranmanesh A, Lizarralde G, Johnson ML, Veldhuis JD. Nature of altered growth hormone secretion in hyperthyroidism. Journal of Clinical Endocrinology and Metabolism. 1991 Jan;72(1):108-115.
Iranmanesh, Ali ; Lizarralde, German ; Johnson, Michael L. ; Veldhuis, Johannes D. / Nature of altered growth hormone secretion in hyperthyroidism. In: Journal of Clinical Endocrinology and Metabolism. 1991 ; Vol. 72, No. 1. pp. 108-115.
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