Naturally occurring hepatitis B virus mutants with deletions in the core promoter region

Tomasz Laskus, Jorge Rakela, Myron J. Tong, Marek J. Nowicki, James W. Mosley, David H. Persing

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A novel class of hepatitis B virus mutants in patients with chronic hepatitis B is described. The predicted effect of the mutations is to disrupt the X open reading frame. The location of the genetic alterations within the putative precore promoter also suggests that they may ameliorate precore transcription, which would provide an alternate mechanism for HBeAg(-) escape variation. Definitive conclusions regarding the effects of these mutations must await additional in vitro and in vivo studies.

Original languageEnglish (US)
Pages (from-to)837-841
Number of pages5
JournalJournal of hepatology
Volume20
Issue number6
DOIs
StatePublished - 1994

Keywords

  • Core promoter
  • Deletion
  • HBeAg

ASJC Scopus subject areas

  • Hepatology

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