Naturally occurring hepatitis B virus mutants with deletions in the core promoter region

Tomasz Laskus; Jorge Rakela; Myron J. Tong; Marek J. Nowicki; James W. Mosley; David H. Persing

doi:10.1016/S0168-8278(05)80158-8

Naturally occurring hepatitis B virus mutants with deletions in the core promoter region

Tomasz Laskus, Jorge Rakela, Myron J. Tong, Marek J. Nowicki, James W. Mosley, David H. Persing

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

A novel class of hepatitis B virus mutants in patients with chronic hepatitis B is described. The predicted effect of the mutations is to disrupt the X open reading frame. The location of the genetic alterations within the putative precore promoter also suggests that they may ameliorate precore transcription, which would provide an alternate mechanism for HBeAg(-) escape variation. Definitive conclusions regarding the effects of these mutations must await additional in vitro and in vivo studies.

Original language	English (US)
Pages (from-to)	837-841
Number of pages	5
Journal	Journal of hepatology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/S0168-8278(05)80158-8
State	Published - 1994

Keywords

Core promoter
Deletion
HBeAg

ASJC Scopus subject areas

Hepatology

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10.1016/S0168-8278(05)80158-8

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@article{9f86e65d9d2c4b6882a0f7c4fada031f,

title = "Naturally occurring hepatitis B virus mutants with deletions in the core promoter region",

abstract = "A novel class of hepatitis B virus mutants in patients with chronic hepatitis B is described. The predicted effect of the mutations is to disrupt the X open reading frame. The location of the genetic alterations within the putative precore promoter also suggests that they may ameliorate precore transcription, which would provide an alternate mechanism for HBeAg(-) escape variation. Definitive conclusions regarding the effects of these mutations must await additional in vitro and in vivo studies.",

keywords = "Core promoter, Deletion, HBeAg",

author = "Tomasz Laskus and Jorge Rakela and Tong, {Myron J.} and Nowicki, {Marek J.} and Mosley, {James W.} and Persing, {David H.}",

note = "Funding Information: This study was supported by Grant CR20 from the Mayo Clinic and Foundation. DHP is supported by Public Health Service grants AI 32403, AR 41497, and AI 30548 from the National Institutes of Health.",

year = "1994",

doi = "10.1016/S0168-8278(05)80158-8",

language = "English (US)",

volume = "20",

pages = "837--841",

journal = "Journal of hepatology",

issn = "0168-8278",

publisher = "Elsevier",

number = "6",

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TY - JOUR

T1 - Naturally occurring hepatitis B virus mutants with deletions in the core promoter region

AU - Laskus, Tomasz

AU - Rakela, Jorge

AU - Tong, Myron J.

AU - Nowicki, Marek J.

AU - Mosley, James W.

AU - Persing, David H.

N1 - Funding Information: This study was supported by Grant CR20 from the Mayo Clinic and Foundation. DHP is supported by Public Health Service grants AI 32403, AR 41497, and AI 30548 from the National Institutes of Health.

PY - 1994

Y1 - 1994

N2 - A novel class of hepatitis B virus mutants in patients with chronic hepatitis B is described. The predicted effect of the mutations is to disrupt the X open reading frame. The location of the genetic alterations within the putative precore promoter also suggests that they may ameliorate precore transcription, which would provide an alternate mechanism for HBeAg(-) escape variation. Definitive conclusions regarding the effects of these mutations must await additional in vitro and in vivo studies.

AB - A novel class of hepatitis B virus mutants in patients with chronic hepatitis B is described. The predicted effect of the mutations is to disrupt the X open reading frame. The location of the genetic alterations within the putative precore promoter also suggests that they may ameliorate precore transcription, which would provide an alternate mechanism for HBeAg(-) escape variation. Definitive conclusions regarding the effects of these mutations must await additional in vitro and in vivo studies.

KW - Core promoter

KW - Deletion

KW - HBeAg

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DO - 10.1016/S0168-8278(05)80158-8

M3 - Article

C2 - 7930487

AN - SCOPUS:0028234459

SN - 0168-8278

VL - 20

SP - 837

EP - 841

JO - Journal of hepatology

JF - Journal of hepatology

IS - 6

ER -

Naturally occurring hepatitis B virus mutants with deletions in the core promoter region

Abstract

Keywords

ASJC Scopus subject areas

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