Natural killer cell activity in cigarette smokers and asbestos workers

L. C. Ginns, Jay H Ryu, P. R. Rogol, N. L. Sprince, L. C. Oliver, C. J. Larsson

Research output: Contribution to journalArticle

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Abstract

In order to evaluate the effects of cigarette smoking and asbestos exposure on cellular immunity, we tested a group of cigarette smokers and asbestos workers for natural killer (NK) activity in the peripheral blood. The mean NK activity in cigarette smokers was lower than in normal subjects (13.7 ± 1.6 versus 29.0 ± 3%; p < 0.05). As a group, the mean NK activity for the asbestos-exposed group was also reduced compared with that of the nonsmoking control group (22.6 ± 3.2%; p < 0.05). When divided according to the smoking status, the asbestos workers who were nonsmokers or ex-smokers showed similar decreases in NK activity compared with normal subjects (19.5 ± 6.2 and 21.2 ± 4.5%, respectively; p < 0.05). A subgroup of asbestos-exposed subjects who currently smoked showed no decrease in NK activity. The data show that NK activity is reduced in the peripheral blood of cigarette smokers and asbestos workers. The relatively normal NK activity found in asbestos workers who also smoked is unexplained. Impairment of NK activity is a potential mechanism for the increased incidence of infection and cancer in smokers and neoplasia in asbestos workers.

Original languageEnglish (US)
Pages (from-to)831-834
Number of pages4
JournalAmerican Review of Respiratory Disease
Volume131
Issue number6
StatePublished - 1985
Externally publishedYes

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Asbestos
Tobacco Products
Natural Killer Cells
Smoking
Cellular Immunity
Neoplasms
Control Groups
Incidence
Infection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Ginns, L. C., Ryu, J. H., Rogol, P. R., Sprince, N. L., Oliver, L. C., & Larsson, C. J. (1985). Natural killer cell activity in cigarette smokers and asbestos workers. American Review of Respiratory Disease, 131(6), 831-834.

Natural killer cell activity in cigarette smokers and asbestos workers. / Ginns, L. C.; Ryu, Jay H; Rogol, P. R.; Sprince, N. L.; Oliver, L. C.; Larsson, C. J.

In: American Review of Respiratory Disease, Vol. 131, No. 6, 1985, p. 831-834.

Research output: Contribution to journalArticle

Ginns, LC, Ryu, JH, Rogol, PR, Sprince, NL, Oliver, LC & Larsson, CJ 1985, 'Natural killer cell activity in cigarette smokers and asbestos workers', American Review of Respiratory Disease, vol. 131, no. 6, pp. 831-834.
Ginns LC, Ryu JH, Rogol PR, Sprince NL, Oliver LC, Larsson CJ. Natural killer cell activity in cigarette smokers and asbestos workers. American Review of Respiratory Disease. 1985;131(6):831-834.
Ginns, L. C. ; Ryu, Jay H ; Rogol, P. R. ; Sprince, N. L. ; Oliver, L. C. ; Larsson, C. J. / Natural killer cell activity in cigarette smokers and asbestos workers. In: American Review of Respiratory Disease. 1985 ; Vol. 131, No. 6. pp. 831-834.
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