Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment

A. S. Rudenski, D. R. Hadden, A. B. Atkinson, L. Kennedy, D. R. Matthews, J. D. Merrett, Barbara A Pockaj, R. C. Turner

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Islet B-cell function and insulin sensitivity were estimated with the aid of a mathematical model from repeated fasting plasma glucose and insulin measurements over a 6 year period in 131 patients with type 2 diabetes mellitus who could be managed satisfactorily on dietary therapy alone. They presented between the ages of 40 and 69 years, and were studied before and after one year of treatment, and then at regular intervals from 12 unit 72 months later. A method of averaging the individual trends by means of a linear model regression technique was used to assess the progression of their diabetes. Dietary management over the first 12 months resulted in weight loss from 118% to 106% average body weight, and improved insulin sensitivity from 26% to 40% of normal (p < 0.001). From 12 to 72 months, the fasting plasma glucose rose at a mean rate of 0.23 mmol/l per year (p < 0.001) despite a rate of weight loss of 0.2% average body weight per year (p < 0.01). The estimated islet B-cell function, expressed as a percentage of normal, decreased significantly (p < 0.05) at a rate of 1.5% per year, with no statistically significant change in insulin sensitivity. Extrapolation suggests the reduction in B-cell function predated the departure of fasting plasma glucose from the normal range.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalDiabetic Medicine
Volume5
Issue number1
StatePublished - 1988
Externally publishedYes

Fingerprint

Insulin-Secreting Cells
Natural History
Islets of Langerhans
Type 2 Diabetes Mellitus
Insulin Resistance
Fasting
Homeostasis
B-Lymphocytes
Glucose
Weight Loss
Linear Models
Body Weight
Reference Values
Theoretical Models
Insulin
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Rudenski, A. S., Hadden, D. R., Atkinson, A. B., Kennedy, L., Matthews, D. R., Merrett, J. D., ... Turner, R. C. (1988). Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment. Diabetic Medicine, 5(1), 36-41.

Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment. / Rudenski, A. S.; Hadden, D. R.; Atkinson, A. B.; Kennedy, L.; Matthews, D. R.; Merrett, J. D.; Pockaj, Barbara A; Turner, R. C.

In: Diabetic Medicine, Vol. 5, No. 1, 1988, p. 36-41.

Research output: Contribution to journalArticle

Rudenski, AS, Hadden, DR, Atkinson, AB, Kennedy, L, Matthews, DR, Merrett, JD, Pockaj, BA & Turner, RC 1988, 'Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment', Diabetic Medicine, vol. 5, no. 1, pp. 36-41.
Rudenski, A. S. ; Hadden, D. R. ; Atkinson, A. B. ; Kennedy, L. ; Matthews, D. R. ; Merrett, J. D. ; Pockaj, Barbara A ; Turner, R. C. / Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment. In: Diabetic Medicine. 1988 ; Vol. 5, No. 1. pp. 36-41.
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