Natural history, growth kinetics, and outcomes of untreated clinically localized renal tumors under active surveillance

Paul L. Crispen, Rosalia Viterbo, Stephen A. Boorjian, Richard E. Greenberg, David Y T Chen, Robert G. Uzzo

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143 Scopus citations

Abstract

BACKGROUND: The growth kinetics of untreated solid organ malignancies are not defined. Radiographic active surveillance (AS) of renal tumors in patients unfit or unwilling to undergo intervention provides an opportunity to quantify the natural history of untreated localized tumors. The authors report the radiographic growth kinetics of renal neoplasms during a period of surveillance. METHODS: The authors identified patients with enhancing renal masses who were radiographically observed for at least 12 months. Clinical and pathological records were reviewed to determine tumor growth kinetics and clinical outcomes. Tumor growth kinetics were expressed in terms of absolute and relative linear and volumetric growth. RESULTS: The authors identified 172 renal tumors in 154 patients under AS. Median tumor diameter and volume on presentation were 2.0 cm (mean, 2.5; range, 0.4-12.0) and 4.18 cm3 (mean, 20.0; range, 0.033-904). Median duration of follow-up was 24 months (mean, 31; range, 12-156). A significant association between presenting tumor size and proportional growth was noted, with smaller tumors growing faster than larger tumors. Thirty-nine percent (68 of 173) of tumors underwent delayed intervention, and 84% (57 of 68) were pathologically malignant. Progression to metastatic disease was noted in 1.3% (2 of 154) of patients. CONCLUSIONS: The authors demonstrated the association between a tumor's volume and subsequent growth, with smaller tumors exhibiting significantly faster volumetric growth than larger tumors, consistent with Gompertzian kinetics. Surveillance of localized renal tumors is associated with a low rate of disease progression in the intermediate term, and suggests potential overtreatment biases in select patients.

Original languageEnglish (US)
Pages (from-to)2844-2852
Number of pages9
JournalCancer
Volume115
Issue number13
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

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Keywords

  • Active surveillance
  • Growth kinetics
  • Kidney neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Crispen, P. L., Viterbo, R., Boorjian, S. A., Greenberg, R. E., Chen, D. Y. T., & Uzzo, R. G. (2009). Natural history, growth kinetics, and outcomes of untreated clinically localized renal tumors under active surveillance. Cancer, 115(13), 2844-2852. https://doi.org/10.1002/cncr.24338