Natural autoantibodies to TCR public idiotopes: potential roles in immunomodulation.

S. F. Schluter, M. K. Adelman, Veena D Taneja, C. David, D. E. Yocum, J. J. Marchalonis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Autoantibodies directed against variable domain epitopes of the alpha/beta T cell receptor (TCR) occur in sera of man, mouse and other vertebrates. Here, we focus upon autoantibodies expressed in human rheumatoid arthritis (RA) and systemic erythematosus (SLE) with parallel studies involving collagen induced arthritis (CIA) in mice transgenic for human HLA-DR conferring resistance or susceptibility to autoimmune disease. We report specificity characterization of polyclonal and monoclonal IgM and IgG autoantibodies from SLE and for IgM monoclonal autoantibodies of RA patients. The data suggests that autoantibodies directed against "public" idiotopes present in the first complementarity determining region (CDR1) and the third framework (FR3) of the Vbeta gene products are generated in response to over-production of autodestructive T cells bearing particular Vbeta gene products and function to modulate (downregulate) the expression of these T cells. Since antibodies of these specificities are present in polyclonal IgG immunoglobulin (IVIG) preparations used for therapeutic purposes, the immunomodulatory effects of antibodies directed against TCR variable domains may account, at least in part, for the efficacy of IVIG preparations in therapy of autoimmune diseases and in the prevention of graft versus host reactions.

Original languageEnglish (US)
Pages (from-to)193-207
Number of pages15
JournalCellular and molecular biology (Noisy-le-Grand, France)
Volume49
Issue number2
StatePublished - Mar 1 2003
Externally publishedYes

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Immunomodulation
T-Cell Antigen Receptor
Autoantibodies
T-cells
Intravenous Immunoglobulins
Graft vs. host reactions
Autoimmune Diseases
Immunoglobulin M
Rheumatoid Arthritis
Bearings (structural)
Immunoglobulin G
Genes
Complementarity Determining Regions
Antigen Receptors, T-Cell, alpha-beta
T-Lymphocytes
Experimental Arthritis
Antibody Specificity
Antibodies
HLA-DR Antigens
Transgenic Mice

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Schluter, S. F., Adelman, M. K., Taneja, V. D., David, C., Yocum, D. E., & Marchalonis, J. J. (2003). Natural autoantibodies to TCR public idiotopes: potential roles in immunomodulation. Cellular and molecular biology (Noisy-le-Grand, France), 49(2), 193-207.

Natural autoantibodies to TCR public idiotopes : potential roles in immunomodulation. / Schluter, S. F.; Adelman, M. K.; Taneja, Veena D; David, C.; Yocum, D. E.; Marchalonis, J. J.

In: Cellular and molecular biology (Noisy-le-Grand, France), Vol. 49, No. 2, 01.03.2003, p. 193-207.

Research output: Contribution to journalArticle

Schluter, SF, Adelman, MK, Taneja, VD, David, C, Yocum, DE & Marchalonis, JJ 2003, 'Natural autoantibodies to TCR public idiotopes: potential roles in immunomodulation.', Cellular and molecular biology (Noisy-le-Grand, France), vol. 49, no. 2, pp. 193-207.
Schluter, S. F. ; Adelman, M. K. ; Taneja, Veena D ; David, C. ; Yocum, D. E. ; Marchalonis, J. J. / Natural autoantibodies to TCR public idiotopes : potential roles in immunomodulation. In: Cellular and molecular biology (Noisy-le-Grand, France). 2003 ; Vol. 49, No. 2. pp. 193-207.
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