Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation

R. Schwartz-Albiez, R. C. Monteiro, M. Rodriguez, C. J. Binder, Y. Shoenfeld

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Natural antibodies are produced by B lymphocytes in the absence of external antigen stimulation. With their ability to recognize self, altered self and foreign antigens, they comprise an important first-line defence against invading pathogens, but are also important for tissue homeostasis. By recognizing oligosaccharides expressed on tumour cells and modified cell surface structures accompanying necrosis, natural antibodies have an important anti-tumorigenic function. IVIg contains a wide spectrum of specificities presented in normal plasma including natural antibodies and has been shown to exert inhibitory effects on tumour cells through a subfraction of anti-vascular endothelial growth factor immunoglobulin (Ig)G antibodies with anti-angiogenic properties. IgA antibodies also have potent immunomodulatory properties, being able to both induce and suppress immune responses. IgA-mediated inhibitory function is able to inhibit several inflammatory diseases including asthma and glomerulonephritis. Autoantibodies of the IgM type, on the other hand, have shown promising results in the treatment of multiple sclerosis. These autoantibodies promote remyelination rather than modulating inflammation. Oxidation-specific epitopes, as found in atherosclerotic lesions and on apoptotic cells, comprise one important target of natural antibodies. By recognizing these epitopes, natural antibodies neutralize proinflammatory responses and mediate atheroprotection.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalClinical and Experimental Immunology
Volume158
Issue numberSUPPL. 1
DOIs
StatePublished - Dec 2009

Fingerprint

Intravenous Immunoglobulins
Autoimmunity
Inflammation
Antibodies
Neoplasms
Autoantibodies
Immunoglobulin A
Epitopes
Autoantigens
Glomerulonephritis
Oligosaccharides
Vascular Endothelial Growth Factor A
Multiple Sclerosis
Immunoglobulin M
Anti-Idiotypic Antibodies
Homeostasis
B-Lymphocytes
Necrosis
Asthma
Immunoglobulin G

Keywords

  • Atherosclerosis
  • Cancer
  • IgA
  • Multiple sclerosis
  • Oxidation-specific epitopes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation. / Schwartz-Albiez, R.; Monteiro, R. C.; Rodriguez, M.; Binder, C. J.; Shoenfeld, Y.

In: Clinical and Experimental Immunology, Vol. 158, No. SUPPL. 1, 12.2009, p. 43-50.

Research output: Contribution to journalArticle

Schwartz-Albiez, R. ; Monteiro, R. C. ; Rodriguez, M. ; Binder, C. J. ; Shoenfeld, Y. / Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation. In: Clinical and Experimental Immunology. 2009 ; Vol. 158, No. SUPPL. 1. pp. 43-50.
@article{76c9a5da00ce4dd8a4c9b0443b438992,
title = "Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation",
abstract = "Natural antibodies are produced by B lymphocytes in the absence of external antigen stimulation. With their ability to recognize self, altered self and foreign antigens, they comprise an important first-line defence against invading pathogens, but are also important for tissue homeostasis. By recognizing oligosaccharides expressed on tumour cells and modified cell surface structures accompanying necrosis, natural antibodies have an important anti-tumorigenic function. IVIg contains a wide spectrum of specificities presented in normal plasma including natural antibodies and has been shown to exert inhibitory effects on tumour cells through a subfraction of anti-vascular endothelial growth factor immunoglobulin (Ig)G antibodies with anti-angiogenic properties. IgA antibodies also have potent immunomodulatory properties, being able to both induce and suppress immune responses. IgA-mediated inhibitory function is able to inhibit several inflammatory diseases including asthma and glomerulonephritis. Autoantibodies of the IgM type, on the other hand, have shown promising results in the treatment of multiple sclerosis. These autoantibodies promote remyelination rather than modulating inflammation. Oxidation-specific epitopes, as found in atherosclerotic lesions and on apoptotic cells, comprise one important target of natural antibodies. By recognizing these epitopes, natural antibodies neutralize proinflammatory responses and mediate atheroprotection.",
keywords = "Atherosclerosis, Cancer, IgA, Multiple sclerosis, Oxidation-specific epitopes",
author = "R. Schwartz-Albiez and Monteiro, {R. C.} and M. Rodriguez and Binder, {C. J.} and Y. Shoenfeld",
year = "2009",
month = "12",
doi = "10.1111/j.1365-2249.2009.04026.x",
language = "English (US)",
volume = "158",
pages = "43--50",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation

AU - Schwartz-Albiez, R.

AU - Monteiro, R. C.

AU - Rodriguez, M.

AU - Binder, C. J.

AU - Shoenfeld, Y.

PY - 2009/12

Y1 - 2009/12

N2 - Natural antibodies are produced by B lymphocytes in the absence of external antigen stimulation. With their ability to recognize self, altered self and foreign antigens, they comprise an important first-line defence against invading pathogens, but are also important for tissue homeostasis. By recognizing oligosaccharides expressed on tumour cells and modified cell surface structures accompanying necrosis, natural antibodies have an important anti-tumorigenic function. IVIg contains a wide spectrum of specificities presented in normal plasma including natural antibodies and has been shown to exert inhibitory effects on tumour cells through a subfraction of anti-vascular endothelial growth factor immunoglobulin (Ig)G antibodies with anti-angiogenic properties. IgA antibodies also have potent immunomodulatory properties, being able to both induce and suppress immune responses. IgA-mediated inhibitory function is able to inhibit several inflammatory diseases including asthma and glomerulonephritis. Autoantibodies of the IgM type, on the other hand, have shown promising results in the treatment of multiple sclerosis. These autoantibodies promote remyelination rather than modulating inflammation. Oxidation-specific epitopes, as found in atherosclerotic lesions and on apoptotic cells, comprise one important target of natural antibodies. By recognizing these epitopes, natural antibodies neutralize proinflammatory responses and mediate atheroprotection.

AB - Natural antibodies are produced by B lymphocytes in the absence of external antigen stimulation. With their ability to recognize self, altered self and foreign antigens, they comprise an important first-line defence against invading pathogens, but are also important for tissue homeostasis. By recognizing oligosaccharides expressed on tumour cells and modified cell surface structures accompanying necrosis, natural antibodies have an important anti-tumorigenic function. IVIg contains a wide spectrum of specificities presented in normal plasma including natural antibodies and has been shown to exert inhibitory effects on tumour cells through a subfraction of anti-vascular endothelial growth factor immunoglobulin (Ig)G antibodies with anti-angiogenic properties. IgA antibodies also have potent immunomodulatory properties, being able to both induce and suppress immune responses. IgA-mediated inhibitory function is able to inhibit several inflammatory diseases including asthma and glomerulonephritis. Autoantibodies of the IgM type, on the other hand, have shown promising results in the treatment of multiple sclerosis. These autoantibodies promote remyelination rather than modulating inflammation. Oxidation-specific epitopes, as found in atherosclerotic lesions and on apoptotic cells, comprise one important target of natural antibodies. By recognizing these epitopes, natural antibodies neutralize proinflammatory responses and mediate atheroprotection.

KW - Atherosclerosis

KW - Cancer

KW - IgA

KW - Multiple sclerosis

KW - Oxidation-specific epitopes

UR - http://www.scopus.com/inward/record.url?scp=72149102130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72149102130&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2249.2009.04026.x

DO - 10.1111/j.1365-2249.2009.04026.x

M3 - Article

C2 - 19883423

AN - SCOPUS:72149102130

VL - 158

SP - 43

EP - 50

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - SUPPL. 1

ER -