Natriuretic peptides: Physiology for the clinician

Siu Hin Wan; Horng Haur Chen

doi:10.1007/978-3-319-42982-3_13

Natriuretic peptides: Physiology for the clinician

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Natriuretic peptides (NPs) are a family of hormones that have significant cardiorenal properties. As an important component of blood pressure homeostasis in humans, NPs are potent vasodilatory hormones that mediate diuresis, natriuresis and cardiac remodeling (Levin et al., N Engl J Med 339(5):321-328, 1998). Neurohormonal signaling plays an essential role in cardiovascular disease. Whereas antagonism of the renin-angiotensin-aldosterone pathway, a mediator of provascocontriction, leads to improved outcomes in heart failure, the potentiation of the NPs leads to vasodilation and improved cardiac remodeling. Therefore, NPs have been investigated both as a biomarker for cardiovascular disease as well as a potential treatment agent.

Original language	English (US)
Title of host publication	Cardiac Biomarkers: Case Studies and Clinical Correlations
Publisher	Springer International Publishing
Pages	161-172
Number of pages	12
ISBN (Electronic)	9783319429823
ISBN (Print)	9783319429809
DOIs	https://doi.org/10.1007/978-3-319-42982-3_13
State	Published - Jan 1 2016

Keywords

Atrial natriuretic peptide (ANP)
B-type natriuretic peptide (BNP)
C-type natriuretic peptide
Cardiovascular properties of natriuretic peptides
Natriuretic peptides
Therapeutic modalities for heart failure

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-3-319-42982-3_13

Cite this

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title = "Natriuretic peptides: Physiology for the clinician",

abstract = "Natriuretic peptides (NPs) are a family of hormones that have significant cardiorenal properties. As an important component of blood pressure homeostasis in humans, NPs are potent vasodilatory hormones that mediate diuresis, natriuresis and cardiac remodeling (Levin et al., N Engl J Med 339(5):321-328, 1998). Neurohormonal signaling plays an essential role in cardiovascular disease. Whereas antagonism of the renin-angiotensin-aldosterone pathway, a mediator of provascocontriction, leads to improved outcomes in heart failure, the potentiation of the NPs leads to vasodilation and improved cardiac remodeling. Therefore, NPs have been investigated both as a biomarker for cardiovascular disease as well as a potential treatment agent.",

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AU - Chen, Horng Haur

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N2 - Natriuretic peptides (NPs) are a family of hormones that have significant cardiorenal properties. As an important component of blood pressure homeostasis in humans, NPs are potent vasodilatory hormones that mediate diuresis, natriuresis and cardiac remodeling (Levin et al., N Engl J Med 339(5):321-328, 1998). Neurohormonal signaling plays an essential role in cardiovascular disease. Whereas antagonism of the renin-angiotensin-aldosterone pathway, a mediator of provascocontriction, leads to improved outcomes in heart failure, the potentiation of the NPs leads to vasodilation and improved cardiac remodeling. Therefore, NPs have been investigated both as a biomarker for cardiovascular disease as well as a potential treatment agent.

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KW - B-type natriuretic peptide (BNP)

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KW - Therapeutic modalities for heart failure

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Natriuretic peptides: Physiology for the clinician

Abstract

Keywords

ASJC Scopus subject areas

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