Natriuretic Peptides in the Diagnosis and Management of Chronic Heart Failure

Guido Boerrigter, Lisa C. Costello-Boerrigter, John C. Burnett

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Circulating levels of the BNP system can help in the diagnosis of cardiovascular disease and provide prognostic information not only for patients who have HF but also for the general population and other patient groups. Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the BNP system are emerging that may improve the diagnostic and prognostic value of BNP. Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases BNP levels) may help to further refine the use of components of the BNP system as biomarkers.

Original languageEnglish (US)
Pages (from-to)501-514
Number of pages14
JournalHeart Failure Clinics
Volume5
Issue number4
DOIs
StatePublished - Oct 1 2009

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Keywords

  • Biomarker
  • Diagnosis
  • Heart failure
  • Natriuretic peptides
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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