Natriuretic Peptides in the Diagnosis and Management of Chronic Heart Failure

Guido Boerrigter; Lisa C. Costello-Boerrigter; John C. Burnett

doi:10.1016/j.hfc.2009.04.002

Natriuretic Peptides in the Diagnosis and Management of Chronic Heart Failure

Guido Boerrigter, Lisa C. Costello-Boerrigter, John C. Burnett

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

Circulating levels of the BNP system can help in the diagnosis of cardiovascular disease and provide prognostic information not only for patients who have HF but also for the general population and other patient groups. Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the BNP system are emerging that may improve the diagnostic and prognostic value of BNP. Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases BNP levels) may help to further refine the use of components of the BNP system as biomarkers.

Original language	English (US)
Pages (from-to)	501-514
Number of pages	14
Journal	Heart Failure Clinics
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/j.hfc.2009.04.002
State	Published - Oct 2009

Keywords

Biomarker
Diagnosis
Heart failure
Natriuretic peptides
Prognosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.hfc.2009.04.002

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title = "Natriuretic Peptides in the Diagnosis and Management of Chronic Heart Failure",

abstract = "Circulating levels of the BNP system can help in the diagnosis of cardiovascular disease and provide prognostic information not only for patients who have HF but also for the general population and other patient groups. Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the BNP system are emerging that may improve the diagnostic and prognostic value of BNP. Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases BNP levels) may help to further refine the use of components of the BNP system as biomarkers.",

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N2 - Circulating levels of the BNP system can help in the diagnosis of cardiovascular disease and provide prognostic information not only for patients who have HF but also for the general population and other patient groups. Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the BNP system are emerging that may improve the diagnostic and prognostic value of BNP. Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases BNP levels) may help to further refine the use of components of the BNP system as biomarkers.

AB - Circulating levels of the BNP system can help in the diagnosis of cardiovascular disease and provide prognostic information not only for patients who have HF but also for the general population and other patient groups. Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the BNP system are emerging that may improve the diagnostic and prognostic value of BNP. Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases BNP levels) may help to further refine the use of components of the BNP system as biomarkers.

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KW - Natriuretic peptides

KW - Prognosis

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Natriuretic Peptides in the Diagnosis and Management of Chronic Heart Failure

Abstract

Keywords

ASJC Scopus subject areas

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