Natriuretic peptides and analytical barriers

Vlad C. Vasile, Allan S. Jaffe

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

BACKGROUND: The natriuretic peptide system is an endocrine, autocrine and paracrine system that plays an important role in the maintenance of cardiovascular homeostasis. Biomarkers based on these peptides are important diagnostic and prognostic tools for myocardial function. CONTENT: Although natriuretic peptides were discovered more than 2 decades ago, their intricate and complex biology is associated with important questions not yet elucidated. The diversity of circulating forms of natriuretic peptides, the distinct expression of these forms in particular patients, and the heterogeneity of heart failure forms, along with specific assay-related and preanalytic issues, cause assays to be poorly harmonized. SUMMARY: This review presents the relevant issues related to the biology of natriuretic peptides and differences between assays with immediate implications for clinical practice.

Original languageEnglish (US)
Pages (from-to)50-58
Number of pages9
JournalClinical chemistry
Volume63
Issue number1
DOIs
StatePublished - Jan 2017

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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