Natriuretic peptide system in human heart failure

Chi Ming Wei, Denise M. Heublein, Mark A. Perrella, Amir Lerman, Richard J. Rodeheffer, Christopher G.A. McGregor, William D. Edwards, Hartzell V. Schaff, John C. Burnett

Research output: Contribution to journalArticle

371 Scopus citations

Abstract

Background. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are a family of structurally related peptides that participate in the integrated control of renal and cardiovascular function. Previous studies suggest a functional role for these hormonal peptides in cardiorenal regulation in congestive heart failure (CHF). Methods and Results. The present studies were performed in normal subjects (n=6) and in patients with mild (New York Heart Association [NYHA] class I to II, n=20) and severe (NYHA class III to IV, n=20) CHF by use of radioimmunoassay and immunohistochemical staining (IHCS). Plasma ANP was significantly increased in both mild and severe CHF compared with normal subjects. In contrast, plasma BNP was only moderately increased in the severe CHF group, and plasma CNP concentration was unchanged in CHF compared with normal subjects. Atrial tissue concentrations of the natriuretic peptides did not parallel circulating concentrations. ANP predominated in normal atrial tissue, but BNP predominated in CHF. In ventricular tissue, IHCS staining was present for all three peptides in normal ventricular myocardium and was markedly enhanced in CHF. Conclusions. These studies support a differential regulation of ANP, BNP, and CNP circulating concentrations and tissue activity in human CHF.

Original languageEnglish (US)
Pages (from-to)1004-1009
Number of pages6
JournalCirculation
Volume88
Issue number3
DOIs
StatePublished - Sep 1993

Keywords

  • Heart failure
  • Left ventricle
  • Natriuretic peptides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Natriuretic peptide system in human heart failure'. Together they form a unique fingerprint.

  • Cite this

    Wei, C. M., Heublein, D. M., Perrella, M. A., Lerman, A., Rodeheffer, R. J., McGregor, C. G. A., Edwards, W. D., Schaff, H. V., & Burnett, J. C. (1993). Natriuretic peptide system in human heart failure. Circulation, 88(3), 1004-1009. https://doi.org/10.1161/01.CIR.88.3.1004