Natriuretic peptide system in human heart failure

C. M. Wei, D. M. Heublein, M. A. Perrella, Amir Lerman, R. J. Rodeheffer, C. G A McGregor, W. D. Edwards, Hartzell V Schaff, John C Jr. Burnett

Research output: Contribution to journalArticle

368 Citations (Scopus)

Abstract

Background. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are a family of structurally related peptides that participate in the integrated control of renal and cardiovascular function. Previous studies suggest a functional role for these hormonal peptides in cardiorenal regulation in congestive heart failure (CHF). Methods and Results. The present studies were performed in normal subjects (n=6) and in patients with mild (New York Heart Association [NYHA] class I to II, n=20) and severe (NYHA class III to IV, n=20) CHF by use of radioimmunoassay and immunohistochemical staining (IHCS). Plasma ANP was significantly increased in both mild and severe CHF compared with normal subjects. In contrast, plasma BNP was only moderately increased in the severe CHF group, and plasma CNP concentration was unchanged in CHF compared with normal subjects. Atrial tissue concentrations of the natriuretic peptides did not parallel circulating concentrations. ANP predominated in normal atrial tissue, but BNP predominated in CHF. In ventricular tissue, IHCS staining was present for all three peptides in normal ventricular myocardium and was markedly enhanced in CHF. Conclusions. These studies support a differential regulation of ANP, BNP, and CNP circulating concentrations and tissue activity in human CHF.

Original languageEnglish (US)
Pages (from-to)1004-1009
Number of pages6
JournalCirculation
Volume88
Issue number3
StatePublished - 1993

Fingerprint

Natriuretic Peptides
Heart Failure
Brain Natriuretic Peptide
C-Type Natriuretic Peptide
Atrial Natriuretic Factor
Staining and Labeling
Peptides
Human Activities
Radioimmunoassay
Myocardium
Kidney

Keywords

  • heart failure
  • left ventricle
  • natriuretic peptides

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Wei, C. M., Heublein, D. M., Perrella, M. A., Lerman, A., Rodeheffer, R. J., McGregor, C. G. A., ... Burnett, J. C. J. (1993). Natriuretic peptide system in human heart failure. Circulation, 88(3), 1004-1009.

Natriuretic peptide system in human heart failure. / Wei, C. M.; Heublein, D. M.; Perrella, M. A.; Lerman, Amir; Rodeheffer, R. J.; McGregor, C. G A; Edwards, W. D.; Schaff, Hartzell V; Burnett, John C Jr.

In: Circulation, Vol. 88, No. 3, 1993, p. 1004-1009.

Research output: Contribution to journalArticle

Wei, CM, Heublein, DM, Perrella, MA, Lerman, A, Rodeheffer, RJ, McGregor, CGA, Edwards, WD, Schaff, HV & Burnett, JCJ 1993, 'Natriuretic peptide system in human heart failure', Circulation, vol. 88, no. 3, pp. 1004-1009.
Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CGA et al. Natriuretic peptide system in human heart failure. Circulation. 1993;88(3):1004-1009.
Wei, C. M. ; Heublein, D. M. ; Perrella, M. A. ; Lerman, Amir ; Rodeheffer, R. J. ; McGregor, C. G A ; Edwards, W. D. ; Schaff, Hartzell V ; Burnett, John C Jr. / Natriuretic peptide system in human heart failure. In: Circulation. 1993 ; Vol. 88, No. 3. pp. 1004-1009.
@article{7d51b3331fc1411caed67a8f1a2f16fe,
title = "Natriuretic peptide system in human heart failure",
abstract = "Background. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are a family of structurally related peptides that participate in the integrated control of renal and cardiovascular function. Previous studies suggest a functional role for these hormonal peptides in cardiorenal regulation in congestive heart failure (CHF). Methods and Results. The present studies were performed in normal subjects (n=6) and in patients with mild (New York Heart Association [NYHA] class I to II, n=20) and severe (NYHA class III to IV, n=20) CHF by use of radioimmunoassay and immunohistochemical staining (IHCS). Plasma ANP was significantly increased in both mild and severe CHF compared with normal subjects. In contrast, plasma BNP was only moderately increased in the severe CHF group, and plasma CNP concentration was unchanged in CHF compared with normal subjects. Atrial tissue concentrations of the natriuretic peptides did not parallel circulating concentrations. ANP predominated in normal atrial tissue, but BNP predominated in CHF. In ventricular tissue, IHCS staining was present for all three peptides in normal ventricular myocardium and was markedly enhanced in CHF. Conclusions. These studies support a differential regulation of ANP, BNP, and CNP circulating concentrations and tissue activity in human CHF.",
keywords = "heart failure, left ventricle, natriuretic peptides",
author = "Wei, {C. M.} and Heublein, {D. M.} and Perrella, {M. A.} and Amir Lerman and Rodeheffer, {R. J.} and McGregor, {C. G A} and Edwards, {W. D.} and Schaff, {Hartzell V} and Burnett, {John C Jr.}",
year = "1993",
language = "English (US)",
volume = "88",
pages = "1004--1009",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Natriuretic peptide system in human heart failure

AU - Wei, C. M.

AU - Heublein, D. M.

AU - Perrella, M. A.

AU - Lerman, Amir

AU - Rodeheffer, R. J.

AU - McGregor, C. G A

AU - Edwards, W. D.

AU - Schaff, Hartzell V

AU - Burnett, John C Jr.

PY - 1993

Y1 - 1993

N2 - Background. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are a family of structurally related peptides that participate in the integrated control of renal and cardiovascular function. Previous studies suggest a functional role for these hormonal peptides in cardiorenal regulation in congestive heart failure (CHF). Methods and Results. The present studies were performed in normal subjects (n=6) and in patients with mild (New York Heart Association [NYHA] class I to II, n=20) and severe (NYHA class III to IV, n=20) CHF by use of radioimmunoassay and immunohistochemical staining (IHCS). Plasma ANP was significantly increased in both mild and severe CHF compared with normal subjects. In contrast, plasma BNP was only moderately increased in the severe CHF group, and plasma CNP concentration was unchanged in CHF compared with normal subjects. Atrial tissue concentrations of the natriuretic peptides did not parallel circulating concentrations. ANP predominated in normal atrial tissue, but BNP predominated in CHF. In ventricular tissue, IHCS staining was present for all three peptides in normal ventricular myocardium and was markedly enhanced in CHF. Conclusions. These studies support a differential regulation of ANP, BNP, and CNP circulating concentrations and tissue activity in human CHF.

AB - Background. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are a family of structurally related peptides that participate in the integrated control of renal and cardiovascular function. Previous studies suggest a functional role for these hormonal peptides in cardiorenal regulation in congestive heart failure (CHF). Methods and Results. The present studies were performed in normal subjects (n=6) and in patients with mild (New York Heart Association [NYHA] class I to II, n=20) and severe (NYHA class III to IV, n=20) CHF by use of radioimmunoassay and immunohistochemical staining (IHCS). Plasma ANP was significantly increased in both mild and severe CHF compared with normal subjects. In contrast, plasma BNP was only moderately increased in the severe CHF group, and plasma CNP concentration was unchanged in CHF compared with normal subjects. Atrial tissue concentrations of the natriuretic peptides did not parallel circulating concentrations. ANP predominated in normal atrial tissue, but BNP predominated in CHF. In ventricular tissue, IHCS staining was present for all three peptides in normal ventricular myocardium and was markedly enhanced in CHF. Conclusions. These studies support a differential regulation of ANP, BNP, and CNP circulating concentrations and tissue activity in human CHF.

KW - heart failure

KW - left ventricle

KW - natriuretic peptides

UR - http://www.scopus.com/inward/record.url?scp=0027162016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027162016&partnerID=8YFLogxK

M3 - Article

C2 - 8353861

AN - SCOPUS:0027162016

VL - 88

SP - 1004

EP - 1009

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 3

ER -