National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Bradley T. Hyman, Creighton H. Phelps, Thomas G. Beach, Eileen H. Bigio, Nigel J. Cairns, Maria C. Carrillo, Dennis W Dickson, Charles Duyckaerts, Matthew P. Frosch, Eliezer Masliah, Suzanne S. Mirra, Peter T. Nelson, Julie A. Schneider, Dietmar Rudolf Thal, Bill Thies, John Q. Trojanowski, Harry V. Vinters, Thomas J. Montine

Research output: Contribution to journalArticle

889 Citations (Scopus)

Abstract

A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalAlzheimer's and Dementia
Volume8
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

National Institute on Aging (U.S.)
Alzheimer Disease
Guidelines
Cerebrovascular Trauma
Consensus
Lewy Body Disease
Amyloid Plaques
Brain Diseases
Sclerosis
Amyloid

Keywords

  • Alzheimer's disease
  • Consensus guidelines
  • Lewy body disease
  • Neuropathology
  • Vascular brain injury

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., ... Montine, T. J. (2012). National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimer's and Dementia, 8(1), 1-13. https://doi.org/10.1016/j.jalz.2011.10.007

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. / Hyman, Bradley T.; Phelps, Creighton H.; Beach, Thomas G.; Bigio, Eileen H.; Cairns, Nigel J.; Carrillo, Maria C.; Dickson, Dennis W; Duyckaerts, Charles; Frosch, Matthew P.; Masliah, Eliezer; Mirra, Suzanne S.; Nelson, Peter T.; Schneider, Julie A.; Thal, Dietmar Rudolf; Thies, Bill; Trojanowski, John Q.; Vinters, Harry V.; Montine, Thomas J.

In: Alzheimer's and Dementia, Vol. 8, No. 1, 01.2012, p. 1-13.

Research output: Contribution to journalArticle

Hyman, BT, Phelps, CH, Beach, TG, Bigio, EH, Cairns, NJ, Carrillo, MC, Dickson, DW, Duyckaerts, C, Frosch, MP, Masliah, E, Mirra, SS, Nelson, PT, Schneider, JA, Thal, DR, Thies, B, Trojanowski, JQ, Vinters, HV & Montine, TJ 2012, 'National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease', Alzheimer's and Dementia, vol. 8, no. 1, pp. 1-13. https://doi.org/10.1016/j.jalz.2011.10.007
Hyman, Bradley T. ; Phelps, Creighton H. ; Beach, Thomas G. ; Bigio, Eileen H. ; Cairns, Nigel J. ; Carrillo, Maria C. ; Dickson, Dennis W ; Duyckaerts, Charles ; Frosch, Matthew P. ; Masliah, Eliezer ; Mirra, Suzanne S. ; Nelson, Peter T. ; Schneider, Julie A. ; Thal, Dietmar Rudolf ; Thies, Bill ; Trojanowski, John Q. ; Vinters, Harry V. ; Montine, Thomas J. / National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. In: Alzheimer's and Dementia. 2012 ; Vol. 8, No. 1. pp. 1-13.
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