National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach

Thomas J. Montine, Creighton H. Phelps, Thomas G. Beach, Eileen H. Bigio, Nigel J. Cairns, Dennis W Dickson, Charles Duyckaerts, Matthew P. Frosch, Eliezer Masliah, Suzanne S. Mirra, Peter T. Nelson, Julie A. Schneider, Dietmar Rudolf Thal, John Q. Trojanowski, Harry V. Vinters, Bradley T. Hyman

Research output: Contribution to journalArticle

864 Citations (Scopus)

Abstract

We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an "ABC" score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalActa Neuropathologica
Volume123
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

National Institute on Aging (U.S.)
Amyloid Plaques
Cerebrovascular Trauma
Alzheimer Disease
Guidelines
Lewy Body Disease
Neurofibrillary Tangles
DNA-Binding Proteins
Sclerosis
Consensus
Staining and Labeling
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience

Cite this

National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease : A practical approach. / Montine, Thomas J.; Phelps, Creighton H.; Beach, Thomas G.; Bigio, Eileen H.; Cairns, Nigel J.; Dickson, Dennis W; Duyckaerts, Charles; Frosch, Matthew P.; Masliah, Eliezer; Mirra, Suzanne S.; Nelson, Peter T.; Schneider, Julie A.; Thal, Dietmar Rudolf; Trojanowski, John Q.; Vinters, Harry V.; Hyman, Bradley T.

In: Acta Neuropathologica, Vol. 123, No. 1, 01.2012, p. 1-11.

Research output: Contribution to journalArticle

Montine, TJ, Phelps, CH, Beach, TG, Bigio, EH, Cairns, NJ, Dickson, DW, Duyckaerts, C, Frosch, MP, Masliah, E, Mirra, SS, Nelson, PT, Schneider, JA, Thal, DR, Trojanowski, JQ, Vinters, HV & Hyman, BT 2012, 'National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach', Acta Neuropathologica, vol. 123, no. 1, pp. 1-11. https://doi.org/10.1007/s00401-011-0910-3
Montine, Thomas J. ; Phelps, Creighton H. ; Beach, Thomas G. ; Bigio, Eileen H. ; Cairns, Nigel J. ; Dickson, Dennis W ; Duyckaerts, Charles ; Frosch, Matthew P. ; Masliah, Eliezer ; Mirra, Suzanne S. ; Nelson, Peter T. ; Schneider, Julie A. ; Thal, Dietmar Rudolf ; Trojanowski, John Q. ; Vinters, Harry V. ; Hyman, Bradley T. / National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease : A practical approach. In: Acta Neuropathologica. 2012 ; Vol. 123, No. 1. pp. 1-11.
@article{2fa38299751a499693652ccfe1a6a55b,
title = "National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach",
abstract = "We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an {"}ABC{"} score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.",
author = "Montine, {Thomas J.} and Phelps, {Creighton H.} and Beach, {Thomas G.} and Bigio, {Eileen H.} and Cairns, {Nigel J.} and Dickson, {Dennis W} and Charles Duyckaerts and Frosch, {Matthew P.} and Eliezer Masliah and Mirra, {Suzanne S.} and Nelson, {Peter T.} and Schneider, {Julie A.} and Thal, {Dietmar Rudolf} and Trojanowski, {John Q.} and Vinters, {Harry V.} and Hyman, {Bradley T.}",
year = "2012",
month = "1",
doi = "10.1007/s00401-011-0910-3",
language = "English (US)",
volume = "123",
pages = "1--11",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease

T2 - A practical approach

AU - Montine, Thomas J.

AU - Phelps, Creighton H.

AU - Beach, Thomas G.

AU - Bigio, Eileen H.

AU - Cairns, Nigel J.

AU - Dickson, Dennis W

AU - Duyckaerts, Charles

AU - Frosch, Matthew P.

AU - Masliah, Eliezer

AU - Mirra, Suzanne S.

AU - Nelson, Peter T.

AU - Schneider, Julie A.

AU - Thal, Dietmar Rudolf

AU - Trojanowski, John Q.

AU - Vinters, Harry V.

AU - Hyman, Bradley T.

PY - 2012/1

Y1 - 2012/1

N2 - We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an "ABC" score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.

AB - We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an "ABC" score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.

UR - http://www.scopus.com/inward/record.url?scp=84857030932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857030932&partnerID=8YFLogxK

U2 - 10.1007/s00401-011-0910-3

DO - 10.1007/s00401-011-0910-3

M3 - Article

C2 - 22101365

AN - SCOPUS:84857030932

VL - 123

SP - 1

EP - 11

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 1

ER -