TY - JOUR
T1 - National cancer institute prostate cancer genetics workshop
AU - Catalona, William J.
AU - Bailey-Wilson, Joan E.
AU - Camp, Nicola J.
AU - Chanock, Stephen J.
AU - Cooney, Kathleen A.
AU - Easton, Douglas F.
AU - Eeles, Rosalind A.
AU - FitzGerald, Liesel M.
AU - Freedman, Matthew L.
AU - Gudmundsson, Julius
AU - Kittles, Rick A.
AU - Margulies, Elliott H.
AU - McGuire, Barry B.
AU - Ostrander, Elaine A.
AU - Rebbeck, Timothy R.
AU - Stanford, Janet L.
AU - Thibodeau, Stephen N.
AU - Witte, John S.
AU - Isaacs, William B.
PY - 2011/5/15
Y1 - 2011/5/15
N2 - Compelling evidence supports a genetic component to prostate cancer susceptibility and aggressiveness. Recent genome-wide association studies have identified more than 30 single-nucleotide polymorphisms associated with prostate cancer susceptibility. It remains unclear, however, whether such genetic variants are associated with disease aggressiveness-one of themost important questions in prostate cancer research today. To help clarify this and substantially expand research in the genetic determinants of prostate cancer aggressiveness, the first National Cancer Institute Prostate Cancer Genetics Workshop assembled researchers to develop plans for a large new research consortium and patient cohort. The workshop reviewed the prior work in this area and addressed the practical issues in planning future studies. With new DNA sequencing technology, the potential application of sequencing information to patient care is emerging. The workshop, therefore, included state-of-the-art presentations by experts on new genotyping technologies, including sequencing and associated bioinformatics issues, which are just beginning to be applied to cancer genetics.
AB - Compelling evidence supports a genetic component to prostate cancer susceptibility and aggressiveness. Recent genome-wide association studies have identified more than 30 single-nucleotide polymorphisms associated with prostate cancer susceptibility. It remains unclear, however, whether such genetic variants are associated with disease aggressiveness-one of themost important questions in prostate cancer research today. To help clarify this and substantially expand research in the genetic determinants of prostate cancer aggressiveness, the first National Cancer Institute Prostate Cancer Genetics Workshop assembled researchers to develop plans for a large new research consortium and patient cohort. The workshop reviewed the prior work in this area and addressed the practical issues in planning future studies. With new DNA sequencing technology, the potential application of sequencing information to patient care is emerging. The workshop, therefore, included state-of-the-art presentations by experts on new genotyping technologies, including sequencing and associated bioinformatics issues, which are just beginning to be applied to cancer genetics.
UR - http://www.scopus.com/inward/record.url?scp=79956068299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79956068299&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-11-0314
DO - 10.1158/0008-5472.CAN-11-0314
M3 - Article
C2 - 21558387
AN - SCOPUS:79956068299
SN - 0008-5472
VL - 71
SP - 3442
EP - 3446
JO - Cancer research
JF - Cancer research
IS - 10
ER -