Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia

M. A. Rank, S. I. Ochkur, J. C. Lewis, H. G. Teaford, L. J. Wesselius, R. A. Helmers, N. A. Lee, P. Nair, J. J. Lee

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The objective of the study was to compare nasal, pharyngeal, and sputum eosinophil peroxidase (EPX) levels with induced sputum eosinophil percentage in 10 adults with poorly controlled asthma and 10 normal controls. EPX was measured using an ELISA and normalized for grams of protein for nasal and pharynx specimens and for mL-gram of protein for sputum. Sputum EPX levels were statistically different between asthma and control subjects (P = 0.024). EPX levels measured in the nasal and pharyngeal swab samples derived from the same patients were also different between asthma and control subjects, each displaying a high degree of significance (P = 0.002). Spearman's correlation coefficients for nasal EPX and pharyngeal EPX levels compared to induced sputum eosinophil percentage were 0.81 (P = 0.0007) and 0.78 (P = 0.0017), respectively. Thus, there is a strong association in a given patient between both nasal and pharyngeal EPX levels and the eosinophil percentage of induced sputum.

Original languageEnglish (US)
Pages (from-to)567-570
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume71
Issue number4
DOIs
StatePublished - Apr 1 2016

Keywords

  • asthma
  • diagnostics
  • eosinophil granule proteins
  • eosinophils
  • sputum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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